| Literature DB >> 20619356 |
Lorena Cristina Santos1, Hesther de Macedo Bousquet, Alyne Melo Pereira, Ana Paula Junqueira-Kipnis, André Kipnis.
Abstract
Tuberculosis (TB) is a serious worldwide public health problem, and drug resistance, particularly multidrug resistance (MDR), is a critical factor involved in TB control. We analyzed Mycobacterium tuberculosis isolates from 132 new TB cases of treatment-naïve patients in Goiás, Brazil by drug susceptibility tests, partial sequencing of the rpoB and katG genes, inhA(C-15T) mutation analysis by PCR, and RFLP-IS6110 genotyping. A high frequency of drug resistance was observed in previously untreated patients (13.6% to at least one antibiotic and 6.1% MDR-TB), and a high rate DNA polymorphism was detected in these strains. These results suggest that the prevalence of resistant TB is underestimated and that resistance in new TB cases was not associated with an outbreak in this region. We recommend routine culture and susceptibility testing for all new TB cases in Goiás for the appropriate treatment and control of this disease. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20619356 DOI： 10.1016/j.meegid.2010.06.018
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342