AIMS AND SCOPE: The aim of the present study was to assess whether a difference exists between intima-media thickness and the left ventricular mass index in healthy nonhypertensive, white-coat hypertensive and sustained hypertensive adolescents. PATIENTS AND METHODS: Fifty-nine normotensive and 120 hypertensive adolescents were enrolled in our study. Hypertensive patients were classified into white-coat hypertension (WCH) and sustained hypertension groups based on 24-h ambulatory blood pressure measurements. Both normotensive and hypertensive individuals underwent routine laboratory tests, intima-media thickness measurements on the common carotid arteries and transthoracic echocardiography to measure the left ventricular mass index (LVMI). RESULTS: Intima-media thickness was higher both in WCH and sustained hypertension compared with healthy normotensive individuals (controls: 0.048 ± 0.01 cm, WCH: 0.056 ± 0.01 cm, sustained hypertension: 0.054 ± 0.012 cm, both P < 0.001 compared with controls, nonsignificant difference between the two hypertensive groups). There was no difference between the LVMI of control individuals and WCH (LVMI: 35.5 ± 10.3 g/m and 37.7 ± 11.2 g/m respectively, P = 0.87). LVMI in sustained hypertension group (LVMI: 44.1 ± 14.1 g/m) was significantly higher both compared with WCH (P < 0.05), and healthy adolescents (P < 0.001). CONCLUSION: Target-organ damage develops in a stepwise fashion in adolescent hypertension. An increased intima-media thickness can be demonstrated not only in the sustained but also in the white-coat form of adolescent hypertension.
AIMS AND SCOPE: The aim of the present study was to assess whether a difference exists between intima-media thickness and the left ventricular mass index in healthy nonhypertensive, white-coat hypertensive and sustained hypertensive adolescents. PATIENTS AND METHODS: Fifty-nine normotensive and 120 hypertensive adolescents were enrolled in our study. Hypertensivepatients were classified into white-coat hypertension (WCH) and sustained hypertension groups based on 24-h ambulatory blood pressure measurements. Both normotensive and hypertensive individuals underwent routine laboratory tests, intima-media thickness measurements on the common carotid arteries and transthoracic echocardiography to measure the left ventricular mass index (LVMI). RESULTS: Intima-media thickness was higher both in WCH and sustained hypertension compared with healthy normotensive individuals (controls: 0.048 ± 0.01 cm, WCH: 0.056 ± 0.01 cm, sustained hypertension: 0.054 ± 0.012 cm, both P < 0.001 compared with controls, nonsignificant difference between the two hypertensive groups). There was no difference between the LVMI of control individuals and WCH (LVMI: 35.5 ± 10.3 g/m and 37.7 ± 11.2 g/m respectively, P = 0.87). LVMI in sustained hypertension group (LVMI: 44.1 ± 14.1 g/m) was significantly higher both compared with WCH (P < 0.05), and healthy adolescents (P < 0.001). CONCLUSION: Target-organ damage develops in a stepwise fashion in adolescent hypertension. An increased intima-media thickness can be demonstrated not only in the sustained but also in the white-coat form of adolescent hypertension.
Authors: Laura Massella; Djalila Mekahli; Dušan Paripović; Larisa Prikhodina; Nathalie Godefroid; Anna Niemirska; Ayşe Ağbaş; Karolina Kalicka; Augustina Jankauskiene; Malgorzata Mizerska-Wasiak; Alberto Caldas Afonso; Rémi Salomon; Georges Deschênes; Gema Ariceta; Z Birsin Özçakar; Ana Teixeira; Ali Duzova; Jérôme Harambat; Tomáš Seeman; Gabriela Hrčková; Adrian Catalin Lungu; Svetlana Papizh; Amira Peco-Antic; Stéphanie De Rechter; Ugo Giordano; Marietta Kirchner; Teresa Lutz; Franz Schaefer; Olivier Devuyst; Elke Wühl; Francesco Emma Journal: Clin J Am Soc Nephrol Date: 2018-04-19 Impact factor: 8.237
Authors: Yosuke Miyashita; Coral Hanevold; Anna Faino; Julia Scher; Marc Lande; Ikuyo Yamaguchi; Joel Hernandez; Alisa Acosta; Donald J Weaver; Jason Thomas; Mahmoud Kallash; Michael Ferguson; Ketan N Patel; Andrew M South; Megan Kelton; Joseph T Flynn Journal: J Pediatr Date: 2022-03-26 Impact factor: 6.314
Authors: Joseph T Flynn; Stephen R Daniels; Laura L Hayman; David M Maahs; Brian W McCrindle; Mark Mitsnefes; Justin P Zachariah; Elaine M Urbina Journal: Hypertension Date: 2014-03-03 Impact factor: 10.190