OBJECTIVES: We examined whether distinct monocyte subsets relate in specific ways to coronary fibrous cap thickness (FCT) in patients with unstable angina pectoris (UAP). METHODS: Forty patients with UAP who underwent percutaneous coronary intervention were enrolled in this study. The changes in the non-culprit FCT were assessed by optical coherence tomography (OCT) at baseline and after 9 months. The distinct monocyte subsets (CD14+CD16-CCR2+ and CD14+CD16+CX3CR1+) were measured by flow cytometry. RESULTS: The percent change in FCT showed significantly negative correlation with the percent changes in CD14+CD16+CX3CR1+ monocytes, but not CD14+CD16-CCR2+ monocytes. In addition, the percent change in CD14+CD16+CX3CR1+ monocytes was significantly decreased in the group of patients who received statin treatment compared with the group of patients who did not. Of interest, there was a close relationship between CD14+CD16+CX3CR1+ monocytes and levels of C-reactive protein, but not lipid profiles, including low-density lipoprotein cholesterol and low-/high-density lipoprotein cholesterol ratio. CONCLUSIONS: CD14+CD16+CX3CR1+ monocytes may have a role in coronary plaque vulnerability.
OBJECTIVES: We examined whether distinct monocyte subsets relate in specific ways to coronary fibrous cap thickness (FCT) in patients with unstable angina pectoris (UAP). METHODS: Forty patients with UAP who underwent percutaneous coronary intervention were enrolled in this study. The changes in the non-culprit FCT were assessed by optical coherence tomography (OCT) at baseline and after 9 months. The distinct monocyte subsets (CD14+CD16-CCR2+ and CD14+CD16+CX3CR1+) were measured by flow cytometry. RESULTS: The percent change in FCT showed significantly negative correlation with the percent changes in CD14+CD16+CX3CR1+ monocytes, but not CD14+CD16-CCR2+ monocytes. In addition, the percent change in CD14+CD16+CX3CR1+ monocytes was significantly decreased in the group of patients who received statin treatment compared with the group of patients who did not. Of interest, there was a close relationship between CD14+CD16+CX3CR1+ monocytes and levels of C-reactive protein, but not lipid profiles, including low-density lipoprotein cholesterol and low-/high-density lipoprotein cholesterol ratio. CONCLUSIONS:CD14+CD16+CX3CR1+ monocytes may have a role in coronary plaque vulnerability.
Authors: Graham Thomas; Robert Tacke; Catherine C Hedrick; Richard N Hanna Journal: Arterioscler Thromb Vasc Biol Date: 2015-04-02 Impact factor: 8.311