| Literature DB >> 20615033 |
Turgut Durduran1, Chao Zhou, Erin M Buckley, Meeri N Kim, Guoqiang Yu, Regine Choe, J William Gaynor, Thomas L Spray, Suzanne M Durning, Stefanie E Mason, Lisa M Montenegro, Susan C Nicolson, Robert A Zimmerman, Mary E Putt, Jiongjiong Wang, Joel H Greenberg, John A Detre, Arjun G Yodh, Daniel J Licht.
Abstract
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.Entities:
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Year: 2010 PMID： 20615033 PMCID： PMC2887915 DOI： 10.1117/1.3425884
Source DB: PubMed Journal: J Biomed Opt ISSN： 1083-3668 Impact factor: 3.170