Literature DB >> 20614555

Learning from failure.

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Abstract

The launch of a new initiative to share data from failed clinical trials of investigational drugs for Alzheimer's disease provides both a promising opportunity to improve drug development in this field, as well as a novel mechanism to learn more from negative trials in general.

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Year:  2010        PMID： 20614555     DOI： 10.1038/nrd3222

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  2 in total

1.  The evolution of trial registration.

Authors: 
Journal:  Nat Rev Drug Discov       Date:  2009-10       Impact factor: 84.694

2.  Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy.

Authors:  R Krishna; B Gumbiner; C Stevens; B Musser; M Mallick; S Suryawanshi; L Maganti; H Zhu; T H Han; L Scherer; B Simpson; D Cosgrove; K Gottesdiener; J Amatruda; B J Rolls; J Blundell; G A Bray; K Fujioka; S B Heymsfield; J A Wagner; G A Herman
Journal:  Clin Pharmacol Ther       Date:  2009-09-09       Impact factor: 6.875
  2 in total
  6 in total

Review 1.  Lost but making progress--Where will new analgesic drugs come from?

Authors:  David Borsook; Richard Hargreaves; Chas Bountra; Frank Porreca
Journal:  Sci Transl Med       Date:  2014-08-13       Impact factor: 17.956

2.  Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment.

Authors:  Jia Yao; Roberta Diaz Brinton
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

3.  Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

Authors:  Prashant R Bharadwaj; Giuseppe Verdile; Renae K Barr; Veer Gupta; John W Steele; M Lenard Lachenmayer; Zhenyu Yue; Michelle E Ehrlich; Gregory Petsko; Shulin Ju; Dagmar Ringe; Sonia E Sankovich; Joanne M Caine; Ian G Macreadie; Sam Gandy; Ralph N Martins
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

4.  The institutional review board is an impediment to human research: the result is more animal-based research.

Authors:  Mark J Rice
Journal:  Philos Ethics Humanit Med       Date:  2011-06-07       Impact factor: 2.464

5.  Is Cardiac Rehabilitation Exercise Feasible for People with Mild Cognitive Impairment?

Authors:  Brittany Intzandt; Sandra E Black; Krista L Lanctôt; Nathan Herrmann; Paul Oh; Laura E Middleton
Journal:  Can Geriatr J       Date:  2015-06-30

Review 6.  Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases.

Authors:  P R Bharadwaj; K A Bates; T Porter; E Teimouri; G Perry; J W Steele; S Gandy; D Groth; R N Martins; Giuseppe Verdile
Journal:  Transl Psychiatry       Date:  2013-12-03       Impact factor: 6.222
  6 in total

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