Literature DB >> 20614269

Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue.

Diana Bell1, Yi-Jue Zhao, Pulivarthi H Rao, Randal S Weber, Adel K El-Naggar.   

Abstract

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

Entities:  

Keywords:  Adenoid cystic carcinoma; Comparative genomic hybridizations; Cytogenetic; Spectral karyotyping; Translocations

Mesh：

Year:  2007        PMID： 20614269      PMCID： PMC2807514          DOI： 10.1007/s12105-007-0030-5

Source DB:  PubMed          Journal:  Head Neck Pathol        ISSN： 1936-055X


  28 in total

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Journal:  Cancer Genet Cytogenet       Date:  2001-07-15

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Journal:  Virchows Arch       Date:  2002-01       Impact factor: 4.064

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Journal:  Cancer Genet Cytogenet       Date:  1996-03

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Journal:  Cancer Genet Cytogenet       Date:  1994-07-15

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Journal:  Genes Chromosomes Cancer       Date:  1994-06       Impact factor: 5.006

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Journal:  Br J Cancer       Date:  1994-07       Impact factor: 7.640
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  4 in total

1.  Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma.

Authors:  Alex Panaccione; Yi Zhang; Yanfang Mi; Yoshitsugu Mitani; Guo Yan; Manju L Prasad; W Hayes McDonald; Adel K El-Naggar; Wendell G Yarbrough; Sergey V Ivanov
Journal:  Oral Oncol       Date:  2017-01-09       Impact factor: 5.337

2.  Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance.

Authors:  Yoshitsugu Mitani; Jie Li; Pulivarthi H Rao; Yi-Jue Zhao; Diana Bell; Scott M Lippman; Randal S Weber; Carlos Caulin; Adel K El-Naggar
Journal:  Clin Cancer Res       Date:  2010-08-11       Impact factor: 12.531

3.  Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome.

Authors:  Yoshitsugu Mitani; Pulivarthi H Rao; P Andrew Futreal; Dianna B Roberts; Philip J Stephens; Yi-Jue Zhao; Li Zhang; Mutsumi Mitani; Randal S Weber; Scott M Lippman; Carlos Caulin; Adel K El-Naggar
Journal:  Clin Cancer Res       Date:  2011-10-05       Impact factor: 12.531

4.  Development and characterization of salivary adenoid cystic carcinoma cell line.

Authors:  Jie Li; Laszlo Perlaky; Pulivarthi Rao; Randal S Weber; Adel K El-Naggar
Journal:  Oral Oncol       Date:  2014-07-30       Impact factor: 5.337
  4 in total

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