Literature DB >> 20614050

Highly sensitive amyloid detection enabled by thioflavin T dimers.

Luoheng Qin1, Julian Vastl, Jianmin Gao.   

Abstract

Fluorescent molecules that specifically target amyloid structures are highly desirable for amyloid research. Herein, we show a dimeric design of thioflavin T improves its binding affinity to Abeta amyloid by up to 70 fold, while not sacrificing the specificity and the "light-up" feature upon amyloid binding.

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Year:  2010        PMID： 20614050     DOI： 10.1039/c005255h

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  12 in total

1.  Discovery of a novel fluorescent probe for the sensitive detection of β-amyloid deposits.

Authors:  Wenming Ren; Mingming Xu; Steven H Liang; Huaijiang Xiang; Li Tang; Minkui Zhang; Dejun Ding; Xin Li; Haiyan Zhang; Youhong Hu
Journal:  Biosens Bioelectron       Date:  2015-08-18       Impact factor: 10.618

2.  Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence.

Authors:  Yu Liu; Charles H Wolstenholme; Gregory C Carter; Hongbin Liu; Hang Hu; Leeann S Grainger; Kun Miao; Matthew Fares; Conner A Hoelzel; Hemant P Yennawar; Gang Ning; Manyu Du; Lu Bai; Xiaosong Li; Xin Zhang
Journal:  J Am Chem Soc       Date:  2018-06-12       Impact factor: 15.419

3.  Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates.

Authors:  Therése Klingstedt; Andreas Aslund; Rozalyn A Simon; Leif B G Johansson; Jeffrey J Mason; Sofie Nyström; Per Hammarström; K Peter R Nilsson
Journal:  Org Biomol Chem       Date:  2011-11-03       Impact factor: 3.876

Review 4.  Insight into amyloid structure using chemical probes.

Authors:  Ashley A Reinke; Jason E Gestwicki
Journal:  Chem Biol Drug Des       Date:  2011-04-26       Impact factor: 2.817

5.  Oligovalent amyloid-binding agents reduce SEVI-mediated enhancement of HIV-1 infection.

Authors:  Christina C Capule; Caitlin Brown; Joanna S Olsen; Stephen Dewhurst; Jerry Yang
Journal:  J Am Chem Soc       Date:  2012-01-03       Impact factor: 15.419

6.  Structure-specific amyloid precipitation in biofluids.

Authors:  M Rodrigues; P Bhattacharjee; A Brinkmalm; D T Do; C M Pearson; S De; A Ponjavic; J A Varela; K Kulenkampff; I Baudrexel; D Emin; F S Ruggeri; J E Lee; A R Carr; T P J Knowles; H Zetterberg; T N Snaddon; S Gandhi; S F Lee; D Klenerman
Journal:  Nat Chem       Date:  2022-07-07       Impact factor: 24.274

7.  Fluorescence Investigation of Interactions Between Novel Benzanthrone Dyes and Lysozyme Amyloid Fibrils.

Authors:  Kateryna Vus; Valeriya Trusova; Galyna Gorbenko; Rohit Sood; Elena Kirilova; Georgiy Kirilov; Inta Kalnina; Paavo Kinnunen
Journal:  J Fluoresc       Date:  2013-12-27       Impact factor: 2.217

8.  Quantitative interrogation of protein co-aggregation using multi-color fluorogenic protein aggregation sensors.

Authors:  Yulong Bai; Wang Wan; Yanan Huang; Wenhan Jin; Haochen Lyu; Qiuxuan Xia; Xuepeng Dong; Zhenming Gao; Yu Liu
Journal:  Chem Sci       Date:  2021-05-20       Impact factor: 9.825

9.  Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.

Authors:  Elena Sanna; Margarida Rodrigues; Steven G Fagan; Timothy S Chisholm; Klara Kulenkampff; David Klenerman; Maria Grazia Spillantini; Franklin I Aigbirhio; Christopher A Hunter
Journal:  Chem Sci       Date:  2021-06-07       Impact factor: 9.825

Review 10.  Noncovalent, Electrostatic Interactions Induce Positively Cooperative Binding of Small Molecules to Alzheimer's and Parkinson's Disease-Related Amyloids.

Authors:  Jessica L Cifelli; Christina C Capule; Jerry Yang
Journal:  ACS Chem Neurosci       Date:  2018-08-02       Impact factor: 5.780
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