Paul C Dimayuga1, Kuang-Yuh Chyu, Bojan Cercek. 1. Oppenheimer Atherosclerotic Research Center, Division of Cardiology, Cedars-Sinai Heart Institute, Los Angeles, California 90048, USA. dimayugap@cshs.org
Abstract
PURPOSE OF REVIEW: Immune modulation of neointimal formation after vascular injury has been investigated for several decades but the complexities involved continue to obscure a clearer understanding of the process. The rapidly changing field of immunology makes this knowledge imperative. RECENT FINDINGS: The review discusses immune factors involved in the response to vascular injury. Although innate immune responses play a predominantly detrimental role, the adaptive immune response is more complex. Mechanisms of T-cell activation, recruitment, as well as possible regulation are highlighted. SUMMARY: Progress in understanding the role of the immune system in the response to arterial injury has been impressive. However, recent findings underscore the need to unravel the intricacies involved such as the kinetics and specific pathways of activation, specificity of immune cell involvement, and identification of targets for therapy. This is relevant in light of the increasing reports of immune factors involved in vascular disease and intervention in the clinical setting.
PURPOSE OF REVIEW: Immune modulation of neointimal formation after vascular injury has been investigated for several decades but the complexities involved continue to obscure a clearer understanding of the process. The rapidly changing field of immunology makes this knowledge imperative. RECENT FINDINGS: The review discusses immune factors involved in the response to vascular injury. Although innate immune responses play a predominantly detrimental role, the adaptive immune response is more complex. Mechanisms of T-cell activation, recruitment, as well as possible regulation are highlighted. SUMMARY: Progress in understanding the role of the immune system in the response to arterial injury has been impressive. However, recent findings underscore the need to unravel the intricacies involved such as the kinetics and specific pathways of activation, specificity of immune cell involvement, and identification of targets for therapy. This is relevant in light of the increasing reports of immune factors involved in vascular disease and intervention in the clinical setting.
Authors: Paul C Dimayuga; Kuang-Yuh Chyu; Jonathan Kirzner; Juliana Yano; Xiaoning Zhao; Jianchang Zhou; Prediman K Shah; Bojan Cercek Journal: PLoS One Date: 2011-05-24 Impact factor: 3.240
Authors: Amit Saxena; Harry Björkbacka; Åsa Ström; Sara Rattik; Katarina E Berg; Maria F Gomez; Gunilla Nordin Fredrikson; Jan Nilsson; Anna Hultgårdh-Nilsson Journal: PLoS One Date: 2012-12-11 Impact factor: 3.240