| Literature DB >> 20610917 |
Sundo Jung1, Yoon-Kyung Park, Jung Hoon Shin, Hyunji Lee, Soo-Young Kim, Gap Ryol Lee, Se-Ho Park.
Abstract
TGF-beta-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.Entities:
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Year: 2010 PMID： 20610917 PMCID： PMC2928927 DOI： 10.3858/emm.2010.42.8.055
Source DB: PubMed Journal: Exp Mol Med ISSN： 1226-3613 Impact factor: 8.718