OBJECTIVE: Depression is associated with higher rates of suicide and lower levels of functioning and quality of life in individuals with epilepsy. The objective of this randomized controlled trial was to determine the effectiveness of PEARLS, a home-based program for managing depression in adult individuals with epilepsy and clinically significant acute and chronic depression. METHODS: Delivered by masters-level counselors, PEARLS is a collaborative care intervention consisting of problem solving treatment, behavioral activation, and psychiatric consultation. Patients were randomly assigned to the PEARLS intervention (N = 40) or usual care (N = 40), and assessed at baseline, 6 months, and 12 months. RESULTS: Compared with patients who received usual care, patients assigned to the PEARLS intervention achieved lower depression severity (P<0.005) (Hopkins Symptoms Checklist-20) and lower suicidal ideation (P = 0.025) over 12 months. CONCLUSIONS: The PEARLS program, a community-integrated, home-based treatment for depression, effectively reduces depressive symptoms in adults with epilepsy and comorbid depression.
RCT Entities:
OBJECTIVE:Depression is associated with higher rates of suicide and lower levels of functioning and quality of life in individuals with epilepsy. The objective of this randomized controlled trial was to determine the effectiveness of PEARLS, a home-based program for managing depression in adult individuals with epilepsy and clinically significant acute and chronic depression. METHODS: Delivered by masters-level counselors, PEARLS is a collaborative care intervention consisting of problem solving treatment, behavioral activation, and psychiatric consultation. Patients were randomly assigned to the PEARLS intervention (N = 40) or usual care (N = 40), and assessed at baseline, 6 months, and 12 months. RESULTS: Compared with patients who received usual care, patients assigned to the PEARLS intervention achieved lower depression severity (P<0.005) (Hopkins Symptoms Checklist-20) and lower suicidal ideation (P = 0.025) over 12 months. CONCLUSIONS: The PEARLS program, a community-integrated, home-based treatment for depression, effectively reduces depressive symptoms in adults with epilepsy and comorbid depression.
Authors: Jeremy D Goldhaber-Fiebert; Lea Prince; Lan Xiao; Nan Lv; Lisa G Rosas; Elizabeth M Venditti; Megan A Lewis; Mark B Snowden; Jun Ma Journal: Obesity (Silver Spring) Date: 2020-04-22 Impact factor: 5.002
Authors: Jun Ma; Lisa Goldman Rosas; Nan Lv; Lan Xiao; Mark B Snowden; Elizabeth M Venditti; Megan A Lewis; Jeremy D Goldhaber-Fiebert; Philip W Lavori Journal: JAMA Date: 2019-03-05 Impact factor: 56.272
Authors: Robin E McGee; Martha Sajatovic; Rakale C Quarells; Erika K Johnson; Hongyan Liu; Tanya M Spruill; Robert T Fraser; Mary Janevic; Cam Escoffery; Nancy J Thompson Journal: Epilepsy Behav Date: 2019-04-08 Impact factor: 2.937
Authors: Martha Sajatovic; Curtis Tatsuoka; Elisabeth Welter; Adam T Perzynski; Kari Colon-Zimmermann; Jamie R Van Doren; Ashley Bukach; Mary Ellen Lawless; Eleanor R Ryan; Katherine Sturniolo; Samden Lhatoo Journal: Epilepsy Behav Date: 2016-10-12 Impact factor: 2.937
Authors: Martha Sajatovic; Erica K Johnson; Robert T Fraser; Kristin A Cassidy; Hongyan Liu; Dilip K Pandey; Rakale C Quarells; Peter Scal; Samantha Schmidt; Ross Shegog; Tanya M Spruill; Mary R Janevic; Curtis Tatsuoka; Barbara C Jobst Journal: Epilepsia Date: 2019-09-05 Impact factor: 5.864
Authors: Lisa G Rosas; Kristen M J Azar; Nan Lv; Lan Xiao; Jeremy D Goldhaber-Fiebert; Mark B Snowden; Elizabeth M Venditti; Megan M Lewis; Andrea N Goldstein-Piekarski; Jun Ma Journal: Am J Prev Med Date: 2020-02-14 Impact factor: 5.043