Literature DB >> 206092

Morphological studies of hamster brain cells transformed in vitro by a human papovavirus BK.

R Tanaka, K Sekiguchi, K Ueki, D H Gilden, H Koprowski.   

Abstract

The cytomorphology and cytogenesis of BK virus-transformed hamster brain cells (HBBK cells) were studied. HBBK cells with indistinct processes showed a tendency to epithelial arrangement as well as characteristics of malignant tumor cells in vitro, and developed long, delicate processes when cell growth was suppressed. Glial fibrillary acidic protein was demonstrated by immunofluorescence in the cytoplasm of almost all HBBK cells. The tumors arising in hamsters after subcutaneous inoculation of HBBK cells were classified as poorly differentiated gliomas. These findings suggest that selective transformation of glial cells in hamster brain cells by BK virus occurred.

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Year:  1978        PMID： 206092     DOI： 10.1007/bf00690442

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  17 in total

1.  Morphological differentiation of cultured mouse glioblastoma cells induced by dibutyryl cyclic adenosine monophosphate.

Authors:  S Sato; T Sugimura; K Yoda; S Fujimura
Journal:  Cancer Res       Date:  1975-09       Impact factor: 12.701

2.  Sarcoma in a hamster inoculated with BK virus, a human papovavirus.

Authors:  K V Shah; R W Daniel; J D Strandberg
Journal:  J Natl Cancer Inst       Date:  1975-04       Impact factor: 13.506

3.  Morphologic observations of brain tumors in PD4 hamsters induced by four strains of avian sarcoma virus.

Authors:  P C Burger; D D Bigner; D J Self
Journal:  Acta Neuropathol       Date:  1973       Impact factor: 17.088

4.  Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy.

Authors:  B L Padgett; D L Walker; G M ZuRhein; R J Eckroade; B H Dessel
Journal:  Lancet       Date:  1971-06-19       Impact factor: 79.321

5.  New human papovavirus (B.K.) isolated from urine after renal transplantation.

Authors:  S D Gardner; A M Field; D V Coleman; B Hulme
Journal:  Lancet       Date:  1971-06-19       Impact factor: 79.321

6.  Neoplastic transformation induced by simian virus 40 in Syrian hamster neuroglial and meningeal cell cultures.

Authors:  H M Shein
Journal:  Arch Gesamte Virusforsch       Date:  1967

7.  Tumor induction by adenovirus type 12 and its target cells in the central nervous system.

Authors:  K Ogawa; K Hamaya; Y Fujii; K Matsuura; T Endo
Journal:  Gan       Date:  1969-08

8.  Malignant transformation of hamster brain cells in vitro by human papovavirus Bk.

Authors:  R Tanaka; H Koprowski; Y Iwasaki
Journal:  J Natl Cancer Inst       Date:  1976-03       Impact factor: 13.506

9.  Prevalence in England of antibody to human polyomavirus (B.k.).

Authors:  S D Gardner
Journal:  Br Med J       Date:  1973-01-13

10.  Human papovavirus (JC): induction of brain tumors in hamsters.

Authors:  D L Walker; B L Padgett; G M ZuRhein; A E Albert; R F Marsh
Journal:  Science       Date:  1973-08-17       Impact factor: 47.728
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  3 in total

1.  Tumorigenic clones of hamster brain cells transformed in vitro by polyoma virus. Ultrastructural and immunohistochemical study.

Authors:  M F Tripier; J Hassoun; C de Micco; G Meyer; M Toga
Journal:  Acta Neuropathol       Date:  1979-12       Impact factor: 17.088

2.  Normal and benzo(a)pyrene-transformed fetal mouse brain cells. II. Ultrastructural study.

Authors:  M F Tripier; P Markovits; D Papadopoulo; M Toga
Journal:  Acta Neuropathol       Date:  1979-08       Impact factor: 17.088

3.  Glial fibrillary acidic protein in medulloblastomas.

Authors:  T Kumanishi; K Washiyama; K Watabe; K Sekiguchi
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088
  3 in total

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