Kelly L Moffitt1, S Lorraine Martin, Brian Walker. 1. Biomolecular Sciences Group, School of Pharmacy, Queen's University of Belfast, Belfast BT97BL, Northern Ireland, UK. k.moffitt@qub.ac.uk
Abstract
OBJECTIVES: The role of proteases in the regulation of apoptosis is becoming increasingly apparent. Whilst many of these proteases are already characterised, some have yet to be identified. Traditionally caspases held the traditional role as the prime mediators of apoptosis; however, attention is now turning towards the contribution made by serine proteases. KEY FINDINGS: As unregulated apoptosis is implicated in various disease states, the emergence of this proteolytic family as apoptotic regulators offers novel and alterative opportunities for therapeutic targets. SUMMARY: This review presents a brief introduction and overview of proteases in general with particular attention given to those involved in apoptotic processing.
OBJECTIVES: The role of proteases in the regulation of apoptosis is becoming increasingly apparent. Whilst many of these proteases are already characterised, some have yet to be identified. Traditionally caspases held the traditional role as the prime mediators of apoptosis; however, attention is now turning towards the contribution made by serine proteases. KEY FINDINGS: As unregulated apoptosis is implicated in various disease states, the emergence of this proteolytic family as apoptotic regulators offers novel and alterative opportunities for therapeutic targets. SUMMARY: This review presents a brief introduction and overview of proteases in general with particular attention given to those involved in apoptotic processing.
Authors: Arun P Wiita; Gerald W Hsu; Chuanyi M Lu; Jonathan H Esensten; James A Wells Journal: Proc Natl Acad Sci U S A Date: 2014-05-12 Impact factor: 11.205
Authors: Arun P Wiita; Etay Ziv; Paul J Wiita; Anatoly Urisman; Olivier Julien; Alma L Burlingame; Jonathan S Weissman; James A Wells Journal: Elife Date: 2013-10-29 Impact factor: 8.140