Literature DB >> 20608667

Synthesis of highly substituted isoquinolone derivatives by nickel-catalyzed annulation of 2-halobenzamides with alkynes.

Chuan-Che Liu1, Kanniyappan Parthasarathy, Chien-Hong Cheng.   

Abstract

An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamides with alkynes is described. This protocol is successfully applied to the total synthesis of oxyavicine with excellent yield.

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Year:  2010        PMID： 20608667     DOI： 10.1021/ol101371c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Nickel-catalyzed C-O/N-H, C-S/N-H, and C-CN/N-H annulation of aromatic amides with alkynes: C-O, C-S, and C-CN activation.

Authors:  Yasuaki Iyori; Rina Ueno; Aoi Morishige; Naoto Chatani
Journal:  Chem Sci       Date:  2020-12-09       Impact factor: 9.825

2.  Nickel-catalyzed C-H/N-H annulation of aromatic amides with alkynes in the absence of a specific chelation system.

Authors:  Atsushi Obata; Yusuke Ano; Naoto Chatani
Journal:  Chem Sci       Date:  2017-07-24       Impact factor: 9.825

3.  Isoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction.

Authors:  Qian Wang; Kumchok C Mgimpatsang; Xin Li; Alexander Dömling
Journal:  J Org Chem       Date:  2021-06-29       Impact factor: 4.354
  3 in total

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