Literature DB >> 20607165

A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.

Kevin L Bicker1, Obiamaka Obianyo, Heather L Rust, Paul R Thompson.   

Abstract

The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity.

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Year:  2010        PMID： 20607165      PMCID： PMC2999663          DOI： 10.1039/c0mb00015a

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  22 in total

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2.  Peptide borono lectins (PBLs): a new tool for glycomics and cancer diagnostics.

Authors:  Yuejiao Zou; Dana L Broughton; Kevin L Bicker; Paul R Thompson; John J Lavigne
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3.  Limitations of the coupling of amino acid mixtures for the preparation of equimolar peptide libraries.

Authors:  J A Boutin; I Gesson; J M Henlin; S Bertin; P H Lambert; J P Volland; J L Fauchère
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4.  Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases.

Authors:  G Huyer; J Kelly; J Moffat; R Zamboni; Z Jia; M J Gresser; C Ramachandran
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5.  Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.

Authors:  Z Songyang; A S Fanning; C Fu; J Xu; S M Marfatia; A H Chishti; A Crompton; A C Chan; J M Anderson; L C Cantley
Journal:  Science       Date:  1997-01-03       Impact factor: 47.728

Review 6.  Arginine methylation an emerging regulator of protein function.

Authors:  Mark T Bedford; Stéphane Richard
Journal:  Mol Cell       Date:  2005-04-29       Impact factor: 17.970

7.  Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.

Authors:  Yuan Luo; Kyouhei Arita; Monica Bhatia; Bryan Knuckley; Young-Ho Lee; Michael R Stallcup; Mamoru Sato; Paul R Thompson
Journal:  Biochemistry       Date:  2006-10-03       Impact factor: 3.162

8.  Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.

Authors:  L S Ai; C H Lin; M Hsieh; C Li
Journal:  Proc Natl Sci Counc Repub China B       Date:  1999-10

9.  Boronic acid based peptidic receptors for pattern-based saccharide sensing in neutral aqueous media, an application in real-life samples.

Authors:  Nicola Y Edwards; Thomas W Sager; John T McDevitt; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2007-10-10       Impact factor: 15.419

10.  Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis.

Authors:  Tanesha C Osborne; Obiamaka Obianyo; Xing Zhang; Xiaodong Cheng; Paul R Thompson
Journal:  Biochemistry       Date:  2007-10-26       Impact factor: 3.162
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  7 in total

Review 1.  Chemical biology of protein arginine modifications in epigenetic regulation.

Authors:  Jakob Fuhrmann; Kathleen W Clancy; Paul R Thompson
Journal:  Chem Rev       Date:  2015-05-13       Impact factor: 60.622

2.  Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1.

Authors:  Heather L Rust; Cecilia I Zurita-Lopez; Steven Clarke; Paul R Thompson
Journal:  Biochemistry       Date:  2011-04-01       Impact factor: 3.162

3.  Arginine Methylation Initiates BMP-Induced Smad Signaling.

Authors:  Jian Xu; A Hongjun Wang; Juan Oses-Prieto; Kalpana Makhijani; Yoko Katsuno; Ming Pei; Leilei Yan; Y George Zheng; Alma Burlingame; Katja Brückner; Rik Derynck
Journal:  Mol Cell       Date:  2013-06-06       Impact factor: 17.970

Review 4.  Current chemical biology approaches to interrogate protein methyltransferases.

Authors:  Minkui Luo
Journal:  ACS Chem Biol       Date:  2012-02-01       Impact factor: 5.100

5.  Chemical Proteomic Profiling of Human Methyltransferases.

Authors:  Benjamin D Horning; Radu M Suciu; Darian A Ghadiri; Olesya A Ulanovskaya; Megan L Matthews; Kenneth M Lum; Keriann M Backus; Steven J Brown; Hugh Rosen; Benjamin F Cravatt
Journal:  J Am Chem Soc       Date:  2016-09-30       Impact factor: 15.419

6.  Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.

Authors:  Myles B C Dillon; Heather L Rust; Paul R Thompson; Kerri A Mowen
Journal:  J Biol Chem       Date:  2013-08-14       Impact factor: 5.157

7.  Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.

Authors:  Allison Eberhardt; Jeanne N Hansen; Jan Koster; Louis T Lotta; Simeng Wang; Emmett Livingstone; Kun Qian; Linda J Valentijn; Yujun George Zheng; Nina F Schor; Xingguo Li
Journal:  Oncotarget       Date:  2016-09-27
  7 in total

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