OBJECTIVES: To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population. METHODS: We enrolled 200 patients with AF (mean age: 67 +/- 13 years) and 158 controls (mean age: 63 +/- 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods. RESULTS: The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01). CONCLUSIONS: In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF. Copyright 2010 S. Karger AG, Basel.
OBJECTIVES: To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population. METHODS: We enrolled 200 patients with AF (mean age: 67 +/- 13 years) and 158 controls (mean age: 63 +/- 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods. RESULTS: The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01). CONCLUSIONS: In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF. Copyright 2010 S. Karger AG, Basel.
Authors: Salim S Virani; Ariel Brautbar; Vei-Vei Lee; Macarthur Elayda; Shehzad Sami; Vijay Nambi; Lorraine Frazier; James M Wilson; James T Willerson; Eric Boerwinkle; Christie M Ballantyne Journal: Am J Cardiol Date: 2011-03-15 Impact factor: 2.778
Authors: J G Smith; P Almgren; G Engström; B Hedblad; P G Platonov; C Newton-Cheh; O Melander Journal: J Intern Med Date: 2012-07-27 Impact factor: 8.989
Authors: Wei-Qi Wei; Qiping Feng; Peter Weeke; William Bush; Magarya S Waitara; Otito F Iwuchukwu; Dan M Roden; Russell A Wilke; Charles M Stein; Joshua C Denny Journal: AMIA Jt Summits Transl Sci Proc Date: 2014-04-07
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