Literature DB >> 2060619

Down-regulation of a kinase defective PKC-alpha.

C Pears1, P J Parker.   

Abstract

A kinase defective mutant of PKC-alpha down-regulates in response to phorbol esters as effectively as the wild-type protein when introduced into COS-1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down-regulation.

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Year:  1991        PMID： 2060619     DOI： 10.1016/0014-5793(91)80776-y

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Studies on the phosphorylation of protein kinase C-alpha.

Authors:  C Pears; S Stabel; S Cazaubon; P J Parker
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

Review 2.  The life and death of protein kinase C.

Authors:  Christine M Gould; Alexandra C Newton
Journal:  Curr Drug Targets       Date:  2008-08       Impact factor: 3.465

3.  Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes.

Authors:  G Hansra; P Garcia-Paramio; C Prevostel; R D Whelan; F Bornancin; P J Parker
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

4.  Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo.

Authors:  M Liyanage; D Frith; E Livneh; S Stabel
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

Review 5.  Protein kinase C isoenzymes: divergence in signal transduction?

Authors:  H Hug; T F Sarre
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

6.  Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.

Authors:  J Zhang; L Wang; J Petrin; W R Bishop; R W Bond
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

7.  Involvement of PKC-alpha in regulatory volume decrease responses and activation of volume-sensitive chloride channels in human cervical cancer HT-3 cells.

Authors:  C Y Chou; M R Shen; K S Hsu; H Y Huang; H C Lin
Journal:  J Physiol       Date:  1998-10-15       Impact factor: 5.182

8.  Nerve growth factor activates calcium-insensitive protein kinase C-epsilon in PC-12 rat pheochromocytoma cells.

Authors:  M Ohmichi; G Zhu; A R Saltiel
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857

9.  Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity.

Authors:  F Rossi; M McNagny; G Smith; J Frampton; T Graf
Journal:  EMBO J       Date:  1996-04-15       Impact factor: 11.598

Review 10.  Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents.

Authors:  A Gescher
Journal:  Br J Cancer       Date:  1992-07       Impact factor: 7.640
  10 in total

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