Literature DB >> 2060584

Dissociation between syncytia formation and HIV spreading. Suppression of syncytia formation does not necessarily reflect inhibition of HIV infection.

G Pantaleo1, G Poli, L Butini, C Fox, A I Dayton, A S Fauci.   

Abstract

In this study, we have observed that a dissociation may occur in vitro between syncytia formation and HIV spreading. Efficient HIV spreading and virus replication occurred either in HIV-infected LFA-1+ lymphocytes treated with anti-LFA-1 mAb or in HIV-infected lymphocytes genetically deficient in LFA-1, despite the fact that syncytia formation was completely suppressed. Therefore, these results indicate that syncytia formation cannot be used as the sole parameter to evaluate the spread of HIV in vitro.

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Year:  1991        PMID： 2060584     DOI： 10.1002/eji.1830210730

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  10 in total

1.  Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1.

Authors:  M B Gomez; J E Hildreth
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

2.  Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4.

Authors:  S Moir; J Perreault; L Poulin
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

3.  Fusion of bovine leukemia virus with target cells monitored by R18 fluorescence and PCR assays.

Authors:  S Zarkik; F Defrise-Quertain; D Portetelle; A Burny; J M Ruysschaert
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

4.  Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection.

Authors:  S Lagaye; M Derrien; E Menu; C Coïto; E Tresoldi; P Mauclère; G Scarlatti; G Chaouat; F Barré-Sinoussi; M Bomsel
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

5.  Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5.

Authors:  W C Olson; G E Rabut; K A Nagashima; D N Tran; D J Anselma; S P Monard; J P Segal; D A Thompson; F Kajumo; Y Guo; J P Moore; P J Maddon; T Dragic
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

6.  Neutralizing antibodies in cats infected with feline immunodeficiency virus.

Authors:  F Tozzini; D Matteucci; P Bandecchi; F Baldinotti; K Siebelink; A Osterhaus; M Bendinelli
Journal:  J Clin Microbiol       Date:  1993-06       Impact factor: 5.948

7.  Replication of a macrophage-tropic strain of human immunodeficiency virus type 1 (HIV-1) in a hybrid cell line, CEMx174, suggests that cellular accessory molecules are required for HIV-1 entry.

Authors:  K A Stefano; R Collman; D Kolson; J Hoxie; N Nathanson; F Gonzalez-Scarano
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

8.  Active immunity against the CD4 receptor by using an antibody antigenized with residues 41-55 of the first extracellular domain.

Authors:  P Lanza; R Billetta; S Antonenko; M Zanetti
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

9.  Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism.

Authors:  C S Dukes; Y Yu; E D Rivadeneira; D L Sauls; H X Liao; B F Haynes; J B Weinberg
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

10.  HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.

Authors:  Isabel Puigdomènech; Marta Massanella; Nuria Izquierdo-Useros; Raul Ruiz-Hernandez; Marta Curriu; Margarita Bofill; Javier Martinez-Picado; Manel Juan; Bonaventura Clotet; Julià Blanco
Journal:  Retrovirology       Date:  2008-03-31       Impact factor: 4.602
  10 in total

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