Literature DB >> 20605710

Anticonvulsant activity of embelin isolated from Embelia ribes.

S Mahendran1, B S Thippeswamy, V P Veerapur, S Badami.   

Abstract

Anticonvulsant activity of embelin (2.5, 5 and 10mg/kg, i.p.) was studied. It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole in a dose dependent manner and the activity was comparable to phenytoin and diazepam. Significant decrease in locomotion revealing its CNS depressant activity was observed. The findings suggest that embelin possess anticonvulsant activity against both grand mal and petit mal epilepsy. 2010 Elsevier GmbH. All rights reserved.

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Year:  2010        PMID： 20605710     DOI： 10.1016/j.phymed.2010.04.002

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  23 in total

1.  Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.

Authors:  B S Thippeswamy; P Nagakannan; B D Shivasharan; S Mahendran; V P Veerapur; S Badami
Journal:  Neurotox Res       Date:  2011-07-13       Impact factor: 3.911

2.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

3.  Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats.

Authors:  Rimpi Arora; Rahul Deshmukh
Journal:  Mol Neurobiol       Date:  2016-10-15       Impact factor: 5.590

Review 4.  Awareness and current knowledge of epilepsy.

Authors:  Asmat Ullah Khan; Muhammad Akram; Muhammad Daniyal; Naheed Akhter; Muhammad Riaz; Naheed Akhtar; Mohammad Ali Shariati; Fozia Anjum; Samreen Gul Khan; Abida Parveen; Saeed Ahmad
Journal:  Metab Brain Dis       Date:  2019-10-11       Impact factor: 3.584

5.  Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice.

Authors:  G Smilin Bell Aseervatham; E Abbirami; T Sivasudha; K Ruckmani
Journal:  Metab Brain Dis       Date:  2019-11-14       Impact factor: 3.584

6.  Potential role of embelin in the prevention of Freund's adjuvant induced inflammation and ROS.

Authors:  H M Kumaraswamy; V Krishna; R Sharath; N D Satyanarayan; P Meghana; R Sandeep Kumar Jain; N Prashanth; H Raja Naika
Journal:  3 Biotech       Date:  2021-12-08       Impact factor: 2.406

7.  Trichosanthes tricuspidata modulates oxidative toxicity in brain hippocampus against pilocarpine induced status epilepticus in mice.

Authors:  G Smilin Bell Aseervatham; Thilagar Sivasudha; Mohan Suganya; Angappan Rameshkumar; Ramachandran Jeyadevi
Journal:  Neurochem Res       Date:  2013-05-18       Impact factor: 3.996

8.  Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models.

Authors:  Jayant Sancheti; Mohd Farooq Shaikh; Rahul Chaudhari; Gauresh Somani; Sachin Patil; Pankaj Jain; Sadhana Sathaye
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-09-25       Impact factor: 3.000

Review 9.  Nanomicellar carriers for targeted delivery of anticancer agents.

Authors:  Xiaolan Zhang; Yixian Huang; Song Li
Journal:  Ther Deliv       Date:  2014-01

10.  Sedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and rats.

Authors:  Pandian Nagakannan; Basavaraj D Shivasharan; Veeresh P Veerapur; Boreddy S Thippeswamy
Journal:  Indian J Pharmacol       Date:  2011-11       Impact factor: 1.200
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