PURPOSE: Recent immunopathologic and MRI findings suggest that tissue damage in neuromyelitis optica (NMO) is not limited to spinal cord and optic nerve, but also in brain. Baseline brain activity can reveal the brain functional changes to the tissue damages and give clues to the pathophysiology of NMO, however, it has never been explored by resting-state functional MRI (fMRI). We used regional amplitude of low frequency fluctuation (ALFF) as an index in resting-state fMRI to investigate how baseline brain activity changes in patients with NMO. METHODS: Resting-state fMRIs collected from seventeen NMO patients and seventeen age- and sex-matched normal controls were compared to investigate the ALFF difference between the two groups. The relationships between ALFF in regions with significant group differences and the EDSS (Expanded Disability Status Scale), disease duration were further explored. RESULTS: Our results showed that NMO patients had significantly decreased ALFF in precuneus, posterior cingulate cortex (PCC) and lingual gyrus; and increased ALFF in middle frontal gyrus, caudate nucleus and thalamus, compared to normal controls. Moderate negative correlations were found between the EDSS and ALFF in the left middle frontal gyrus (r=-0.436, p=0.040) and the left caudate (r=-0.542, p=0.012). CONCLUSION: The abnormal baseline brain activity shown by resting-state fMRI in NMO is relevant to cognition, visual and motor systems. It implicates a complex baseline brain status of both functional impairments and adaptations caused by tissue damages in these systems, which gives clues to the pathophysiology of NMO.
PURPOSE: Recent immunopathologic and MRI findings suggest that tissue damage in neuromyelitis optica (NMO) is not limited to spinal cord and optic nerve, but also in brain. Baseline brain activity can reveal the brain functional changes to the tissue damages and give clues to the pathophysiology of NMO, however, it has never been explored by resting-state functional MRI (fMRI). We used regional amplitude of low frequency fluctuation (ALFF) as an index in resting-state fMRI to investigate how baseline brain activity changes in patients with NMO. METHODS: Resting-state fMRIs collected from seventeen NMO patients and seventeen age- and sex-matched normal controls were compared to investigate the ALFF difference between the two groups. The relationships between ALFF in regions with significant group differences and the EDSS (Expanded Disability Status Scale), disease duration were further explored. RESULTS: Our results showed that NMO patients had significantly decreased ALFF in precuneus, posterior cingulate cortex (PCC) and lingual gyrus; and increased ALFF in middle frontal gyrus, caudate nucleus and thalamus, compared to normal controls. Moderate negative correlations were found between the EDSS and ALFF in the left middle frontal gyrus (r=-0.436, p=0.040) and the left caudate (r=-0.542, p=0.012). CONCLUSION: The abnormal baseline brain activity shown by resting-state fMRI in NMO is relevant to cognition, visual and motor systems. It implicates a complex baseline brain status of both functional impairments and adaptations caused by tissue damages in these systems, which gives clues to the pathophysiology of NMO.
Authors: Stephane Kremer; Felix Renard; Sophie Achard; Marco A Lana-Peixoto; Jacqueline Palace; Nasrin Asgari; Eric C Klawiter; Silvia N Tenembaum; Brenda Banwell; Benjamin M Greenberg; Jeffrey L Bennett; Michael Levy; Pablo Villoslada; Albert Saiz; Kazuo Fujihara; Koon Ho Chan; Sven Schippling; Friedemann Paul; Ho Jin Kim; Jerome de Seze; Jens T Wuerfel; Philippe Cabre; Romain Marignier; Thomas Tedder; Danielle van Pelt; Simon Broadley; Tanuja Chitnis; Dean Wingerchuk; Lekha Pandit; Maria Isabel Leite; Metha Apiwattanakul; Ingo Kleiter; Naraporn Prayoonwiwat; May Han; Kerstin Hellwig; Katja van Herle; Gareth John; D Craig Hooper; Ichiro Nakashima; Douglas Sato; Michael R Yeaman; Emmanuelle Waubant; Scott Zamvil; Olaf Stüve; Orhan Aktas; Terry J Smith; Anu Jacob; Kevin O'Connor Journal: JAMA Neurol Date: 2015-07 Impact factor: 18.302
Authors: Laura Clarke; Simon Arnett; Kate Lilley; Jacky Liao; Sandeep Bhuta; Simon A Broadley Journal: Clin Exp Immunol Date: 2021-07-06 Impact factor: 4.330