Literature DB >> 20605675

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma.

Nelson S Yee1, Weiqiang Zhou, Minsun Lee.   

Abstract

The roles of transient receptor potential (TRP) cation channels in pancreatic tumorigenesis are essentially unknown. Here, we focus on the TRP melastatin-subfamily (TRPM) members. Expression of the thermally regulated transmembrane Ca(2+)-permeable channel TRPM8 is consistently up-regulated in human pancreatic adenocarcinoma cell lines and tissues. TRPM8-deficient pancreatic cancer cells have reduced ability of proliferation and cell cycle progression with elevated levels of cyclin-dependent kinase inhibitors. These results indicate that TRPM8 is aberrantly over-expressed in pancreatic adenocarcinoma and required for cellular proliferation, and they support further investigation of the potential of TRPM8 as a clinical biomarker and therapeutic target in pancreatic adenocarcinoma. 2010 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20605675      PMCID： PMC2933954          DOI： 10.1016/j.canlet.2010.04.023

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  26 in total

1.  Identification of a cold receptor reveals a general role for TRP channels in thermosensation.

Authors:  David D McKemy; Werner M Neuhausser; David Julius
Journal:  Nature       Date:  2002-02-10       Impact factor: 49.962

Review 2.  TRP channels as cellular sensors.

Authors:  David E Clapham
Journal:  Nature       Date:  2003-12-04       Impact factor: 49.962

Review 3.  Pathways of apoptotic and non-apoptotic death in tumour cells.

Authors:  Hitoshi Okada; Tak W Mak
Journal:  Nat Rev Cancer       Date:  2004-08       Impact factor: 60.716

Review 4.  TRP channels as potential drug targets.

Authors:  Ulrich Wissenbach; Barbara A Niemeyer; Veit Flockerzi
Journal:  Biol Cell       Date:  2004-02       Impact factor: 4.458

5.  Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells.

Authors:  Lei Zhang; Gregory John Barritt
Journal:  Cancer Res       Date:  2004-11-15       Impact factor: 12.701

6.  Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

Authors:  L M Duncan; J Deeds; J Hunter; J Shao; L M Holmgren; E A Woolf; R I Tepper; A W Shyjan
Journal:  Cancer Res       Date:  1998-04-01       Impact factor: 12.701

7.  Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.

Authors:  D Prawitt; T Enklaar; G Klemm; B Gärtner; C Spangenberg; A Winterpacht; M Higgins; J Pelletier; B Zabel
Journal:  Hum Mol Genet       Date:  2000-01-22       Impact factor: 6.150

8.  Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16.

Authors:  T Furukawa; W P Duguid; L Rosenberg; J Viallet; D A Galloway; M S Tsao
Journal:  Am J Pathol       Date:  1996-06       Impact factor: 4.307

9.  A TRP channel that senses cold stimuli and menthol.

Authors:  Andrea M Peier; Aziz Moqrich; Anne C Hergarden; Alison J Reeve; David A Andersson; Gina M Story; Taryn J Earley; Ilaria Dragoni; Peter McIntyre; Stuart Bevan; Ardem Patapoutian
Journal:  Cell       Date:  2002-03-08       Impact factor: 41.582

10.  Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer.

Authors:  Stephen G Chun; Weiqiang Zhou; Nelson S Yee
Journal:  Cancer Biol Ther       Date:  2009-07-06       Impact factor: 4.742
View more
  41 in total

1.  Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma.

Authors:  Nelson S Yee; Weiqiang Zhou; Minsun Lee; Rosemary K Yee
Journal:  Cancer Lett       Date:  2011-12-11       Impact factor: 8.679

Review 2.  TRPM channels: same ballpark, different players, and different rules in immunogenetics.

Authors:  Ammad Ahmad Farooqi; Mohammed Khalid Javeed; Zeeshan Javed; Asma M Riaz; Shahzeray Mukhtar; Sehrish Minhaj; Sana Abbas; Shahzad Bhatti
Journal:  Immunogenetics       Date:  2011-09-20       Impact factor: 2.846

Review 3.  Regulation of TRPM8 channel activity.

Authors:  Yevgen Yudin; Tibor Rohacs
Journal:  Mol Cell Endocrinol       Date:  2011-10-28       Impact factor: 4.102

Review 4.  Calcium channels and pumps in cancer: changes and consequences.

Authors:  Gregory R Monteith; Felicity M Davis; Sarah J Roberts-Thomson
Journal:  J Biol Chem       Date:  2012-07-20       Impact factor: 5.157

5.  Over-expression of TRPM8 is associated with poor prognosis in urothelial carcinoma of bladder.

Authors:  Ning Xiao; Lei M Jiang; Bo Ge; Tian Y Zhang; Xiao K Zhao; Xing Zhou
Journal:  Tumour Biol       Date:  2014-08-16

Review 6.  TRPM8 and prostate: a cold case?

Authors:  Lucile Noyer; Guillaume P Grolez; Natalia Prevarskaya; Dimitra Gkika; Loic Lemonnier
Journal:  Pflugers Arch       Date:  2018-06-20       Impact factor: 3.657

7.  TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target.

Authors:  Nelson S Yee; Robert D Brown; Min Sun Lee; Weiqiang Zhou; Chris Jensen; Henning Gerke; Rosemary K Yee
Journal:  Cancer Biol Ther       Date:  2012-06-01       Impact factor: 4.742

8.  Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.

Authors:  Nelson S Yee; Abid A Kazi; Rosemary K Yee
Journal:  Zebrafish       Date:  2013-05-17       Impact factor: 1.985

9.  Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis.

Authors:  Yi Qin; Zhi-Wei Liao; Jing-Yan Luo; Wen-Zhe Wu; An-Shang Lu; Pu-Xia Su; Bing-Quan Lai; Xiao-Xiao Wang
Journal:  Tumour Biol       Date:  2016-01-15

Review 10.  Interaction of tumour cells with their microenvironment: ion channels and cell adhesion molecules. A focus on pancreatic cancer.

Authors:  Annarosa Arcangeli; Olivia Crociani; Lapo Bencini
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-02-03       Impact factor: 6.237
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.