Literature DB >> 2060531

Studies of the susceptibility of Pneumocystis carinii to clindamycin/primaquine in rats.

J W Smith1.   

Abstract

Studies in rat models showed that the combination of primaquine plus clindamycin was effective in the therapy and prophylaxis of Pneumocystis carinii pneumonia and that the combination was more effective than either drug alone. These studies formed the basis of ongoing clinical therapy studies and provide a basis for clinical studies of prophylactic efficacy.

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Year:  1991        PMID： 2060531     DOI： 10.1007/bf01964464

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  9 in total

1.  RNA homology and the reclassification of Pneumocystis.

Authors:  J K Frenkel; M S Bartlett; J W Smith
Journal:  Diagn Microbiol Infect Dis       Date:  1990 Jan-Feb       Impact factor: 2.803

2.  Antimalarial effects of clindamycin in man.

Authors:  D F Clyde; R H Gilman; V C McCarthy
Journal:  Am J Trop Med Hyg       Date:  1975-03       Impact factor: 2.345

3.  Pneumocystis carinii: sequence from ribosomal RNA implies a close relationship with fungi.

Authors:  S L Stringer; J R Stringer; M A Blase; P D Walzer; M T Cushion
Journal:  Exp Parasitol       Date:  1989-05       Impact factor: 2.011

4.  Pneumocystis carinii: taxing taxonomy.

Authors:  W T Hughes
Journal:  Eur J Epidemiol       Date:  1989-09       Impact factor: 8.082

5.  Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; J D Richardson; M M Durkin; M A Jay; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

6.  Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients.

Authors:  W D Snider; D M Simpson; S Nielsen; J W Gold; C E Metroka; J B Posner
Journal:  Ann Neurol       Date:  1983-10       Impact factor: 10.422

7.  Enhancement of the curative activity of primaquine by concomitant administration of mirincamycin.

Authors:  L H Schmidt
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

8.  Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients.

Authors:  B A Navia; C K Petito; J W Gold; E S Cho; B D Jordan; R W Price
Journal:  Ann Neurol       Date:  1986-03       Impact factor: 10.422

9.  Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi.

Authors:  J C Edman; J A Kovacs; H Masur; D V Santi; H J Elwood; M L Sogin
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962
  9 in total

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