| Literature DB >> 20604892 |
X Feng1, Y-Z Li, Y Zhang, S-M Bao, D-W Tong, S-L Zhang, C-J Hu.
Abstract
This study aimed at examining the association of the single nucleotide polymorphism (SNP) in the protein tyrosine phosphatase gene (PTPN22) with the risk of rheumatoid arthritis (RA) in a Chinese population. A total of 200 RA patients and age and gender-matched healthy controls were recruited. Their genotypes and allelic frequency were determined by the TaqMan-MGB probe-based polymerase chain reaction (PCR). The frequencies of the CC genotype and C allele in RA patient group were significantly higher than that of controls (P < 0.01 or P < 0.05) with an odds ratio of 1.67, respectively. These data suggest, the CC genotype and C allele of the -1123G > C in the PTPN22 gene are associated with an increased risk for RA in Chinese population. Therefore, the CC genotype and C allele of the -1123G > C in the PTPN22 gene may be used as a genetic marker for the predisposition of RA in Chinese.Entities:
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Year: 2010 PMID： 20604892 DOI： 10.1111/j.1399-0039.2010.01521.x
Source DB: PubMed Journal: Tissue Antigens ISSN： 0001-2815