OBJECTIVE: In Stroop-like tasks, the detection of conflict triggers adjustments of cognitive control to reduce conflict in subsequent trials. The present study tested the hypothesis of an impaired modulation of conflict monitoring in Parkinson's disease (PD). METHOD: 18 PD patients and 18 healthy control (HC) participants performed a Stroop-like task in 2 conditions differing in terms of incongruent/congruent stimuli ratio. RESULTS: HC participants demonstrated a sustained modulation of interference effect, the interference effect being decreased when the proportion of incongruent stimuli was high. A trial-by-trial analysis also showed that in the HC group, processing an incongruent stimulus reduced interference in the subsequent trial. Unlike controls, PD patients did not demonstrate any transient or sustained reduction of the interference effect. CONCLUSION: Within the framework of recent models, these results can be interpreted as an impairment of a proactive mode of cognitive control in patients with PD.
OBJECTIVE: In Stroop-like tasks, the detection of conflict triggers adjustments of cognitive control to reduce conflict in subsequent trials. The present study tested the hypothesis of an impaired modulation of conflict monitoring in Parkinson's disease (PD). METHOD: 18 PDpatients and 18 healthy control (HC) participants performed a Stroop-like task in 2 conditions differing in terms of incongruent/congruent stimuli ratio. RESULTS: HC participants demonstrated a sustained modulation of interference effect, the interference effect being decreased when the proportion of incongruent stimuli was high. A trial-by-trial analysis also showed that in the HC group, processing an incongruent stimulus reduced interference in the subsequent trial. Unlike controls, PDpatients did not demonstrate any transient or sustained reduction of the interference effect. CONCLUSION: Within the framework of recent models, these results can be interpreted as an impairment of a proactive mode of cognitive control in patients with PD.
Authors: Nelleke C Van Wouwe; Daniel O Claassen; Joseph S Neimat; Kristen E Kanoff; Scott A Wylie Journal: J Cogn Neurosci Date: 2017-01-27 Impact factor: 3.225
Authors: Jean-Luc Houeto; Robin Magnard; Jeffrey W Dalley; David Belin; Sebastien Carnicella Journal: Front Psychiatry Date: 2016-05-30 Impact factor: 4.157
Authors: Vignesh Muralidharan; Pragathi P Balasubramani; V Srinivasa Chakravarthy; Moran Gilat; Simon J G Lewis; Ahmed A Moustafa Journal: Front Hum Neurosci Date: 2017-01-09 Impact factor: 3.169