OBJECTIVE: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). METHOD: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). RESULTS: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. CONCLUSION: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
OBJECTIVE: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). METHOD: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). RESULTS: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. CONCLUSION: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
Authors: Robert S Wilson; L L Barnes; C F Mendes de Leon; N T Aggarwal; J S Schneider; J Bach; J Pilat; L A Beckett; S E Arnold; D A Evans; D A Bennett Journal: Neurology Date: 2002-08-13 Impact factor: 9.910
Authors: Hélène Amieva; Mélanie Le Goff; Xavier Millet; Jean Marc Orgogozo; Karine Pérès; Pascale Barberger-Gateau; Hélène Jacqmin-Gadda; Jean François Dartigues Journal: Ann Neurol Date: 2008-11 Impact factor: 10.422
Authors: Kumar B Rajan; Robert S Wilson; Kimberly A Skarupski; Carlos F Mendes de Leon; Denis A Evans Journal: Psychosom Med Date: 2014-01-16 Impact factor: 4.312
Authors: Robert S Wilson; Patricia A Boyle; Eisuke Segawa; Lei Yu; Christopher T Begeny; Sophia E Anagnos; David A Bennett Journal: Psychol Aging Date: 2013-02-18
Authors: L Chouliaras; A S R Sierksma; G Kenis; J Prickaerts; M A M Lemmens; I Brasnjevic; E L van Donkelaar; P Martinez-Martinez; M Losen; M H De Baets; N Kholod; F van Leeuwen; P R Hof; J van Os; H W M Steinbusch; D L A van den Hove; B P F Rutten Journal: Int J Alzheimers Dis Date: 2010-10-05
Authors: Robert S Wilson; Ana W Capuano; Patricia A Boyle; George M Hoganson; Loren P Hizel; Raj C Shah; Sukriti Nag; Julie A Schneider; Steven E Arnold; David A Bennett Journal: Neurology Date: 2014-07-30 Impact factor: 9.910
Authors: Deborah E Barnes; Kristine Yaffe; Amy L Byers; Mark McCormick; Catherine Schaefer; Rachel A Whitmer Journal: Arch Gen Psychiatry Date: 2012-05
Authors: Robert S Wilson; Sukriti Nag; Patricia A Boyle; Loren P Hizel; Lei Yu; Aron S Buchman; Raj C Shah; Julia A Schneider; Steven E Arnold; David A Bennett Journal: JAMA Psychiatry Date: 2013-12 Impact factor: 21.596
Authors: William S Kremen; Margie E Lachman; Jens C Pruessner; Martin Sliwinski; Robert S Wilson Journal: J Gerontol A Biol Sci Med Sci Date: 2012-05-08 Impact factor: 6.053