BACKGROUND: There is evidence that the use of any psychotropic and the concomitant use of two or more benzodiazepines are related to an increased risk of fractures in old age. However, also controversial results exist. The aim was to describe associations between the use of a psychotropic drug, or the concomitant use of two or more of these drugs and the risk of fractures in a population aged 65 years or over. METHODS: This study was a part of a prospective longitudinal population-based study carried out in the municipality of Lieto, South-Western Finland. The objective was to describe gender-specific associations between the use of one psychotropic drug [benzodiazepine (BZD), antipsychotic (AP) or antidepressant (AD)] or the concomitant use of two or more psychotropic drugs and the risk of fractures in a population 65 years or over. Subjects were participants in the first wave of the Lieto study in 1990-1991, and they were followed up until the end of 1996. Information about fractures confirmed with radiology reports in 1,177 subjects (482 men and 695 women) during the follow-up was collected from medical records. Two follow-up periods (three and six years) were used, and previously found risk factors of fractures were adjusted as confounding factors separately for men and women. The Poisson regression model was used in the analyses. RESULTS: The concomitant use of two or more BZDs and the concomitant use of two or more APs were related to an increased risk of fractures during both follow-up periods after adjusting for confounding factors in men. No similar associations were found in women. CONCLUSIONS: The concomitant use of several BZDs and that of several APs are associated with an increase in the risk of fractures in older men. Our findings show only risk relations. We cannot draw the conclusion that these drug combinations are causes of fractures.
BACKGROUND: There is evidence that the use of any psychotropic and the concomitant use of two or more benzodiazepines are related to an increased risk of fractures in old age. However, also controversial results exist. The aim was to describe associations between the use of a psychotropic drug, or the concomitant use of two or more of these drugs and the risk of fractures in a population aged 65 years or over. METHODS: This study was a part of a prospective longitudinal population-based study carried out in the municipality of Lieto, South-Western Finland. The objective was to describe gender-specific associations between the use of one psychotropic drug [benzodiazepine (BZD), antipsychotic (AP) or antidepressant (AD)] or the concomitant use of two or more psychotropic drugs and the risk of fractures in a population 65 years or over. Subjects were participants in the first wave of the Lieto study in 1990-1991, and they were followed up until the end of 1996. Information about fractures confirmed with radiology reports in 1,177 subjects (482 men and 695 women) during the follow-up was collected from medical records. Two follow-up periods (three and six years) were used, and previously found risk factors of fractures were adjusted as confounding factors separately for men and women. The Poisson regression model was used in the analyses. RESULTS: The concomitant use of two or more BZDs and the concomitant use of two or more APs were related to an increased risk of fractures during both follow-up periods after adjusting for confounding factors in men. No similar associations were found in women. CONCLUSIONS: The concomitant use of several BZDs and that of several APs are associated with an increase in the risk of fractures in older men. Our findings show only risk relations. We cannot draw the conclusion that these drug combinations are causes of fractures.
Authors: Carl T Hasselman; Molly T Vogt; Katie L Stone; Jane A Cauley; Stephen F Conti Journal: J Bone Joint Surg Am Date: 2003-05 Impact factor: 5.284
Authors: Carolina H Y Ling; Diana Taekema; Anton J M de Craen; Jacobijn Gussekloo; Rudi G J Westendorp; Andrea B Maier Journal: CMAJ Date: 2010-02-08 Impact factor: 8.262
Authors: Kristine E Ensrud; Terri Blackwell; Carol M Mangione; Paula J Bowman; Douglas C Bauer; Ann Schwartz; Joseph T Hanlon; Michael C Nevitt; Mary A Whooley Journal: Arch Intern Med Date: 2003-04-28
Authors: Peggy Mannen Cawthon; Kathleen M Fox; Shravanthi R Gandra; Matthew J Delmonico; Chiun-Fang Chiou; Mary S Anthony; Ase Sewall; Bret Goodpaster; Suzanne Satterfield; Steven R Cummings; Tamara B Harris Journal: J Am Geriatr Soc Date: 2009-08 Impact factor: 5.562
Authors: Gary M Kiebzak; Garth A Beinart; Karen Perser; Catherine G Ambrose; Sherwin J Siff; Michael H Heggeness Journal: Arch Intern Med Date: 2002-10-28
Authors: J Kellogg Parsons; Jolee Mougey; Lori Lambert; Timothy J Wilt; Howard A Fink; Mark Garzotto; Elizabeth Barrett-Connor; Lynn M Marshall Journal: BJU Int Date: 2009-01-19 Impact factor: 5.588
Authors: Anna Ballokova; Nancye M Peel; Daniela Fialova; Ian A Scott; Leonard C Gray; Ruth E Hubbard Journal: Drugs Aging Date: 2014-04 Impact factor: 3.923
Authors: Allen R Huang; Louise Mallet; Christian M Rochefort; Tewodros Eguale; David L Buckeridge; Robyn Tamblyn Journal: Drugs Aging Date: 2012-05-01 Impact factor: 3.923
Authors: Lorraine C Mion; A Michelle Chandler; Teresa M Waters; Mary S Dietrich; Lori A Kessler; Stephen T Miller; Ronald I Shorr Journal: Jt Comm J Qual Patient Saf Date: 2012-09
Authors: Robyn Tamblyn; Tewodros Eguale; David L Buckeridge; Allen Huang; James Hanley; Kristen Reidel; Sherry Shi; Nancy Winslade Journal: J Am Med Inform Assoc Date: 2012-01-12 Impact factor: 4.497