BACKGROUND: It is uncertain which baseline factors are associated with graft-related complications and reinterventions after endovascular aneurysm repair (EVAR) in patients with a large abdominal aortic aneurysm. METHODS: Patients randomized to elective EVAR in EVAR Trial 1 or 2 were followed for serious graft-related complications (type 2 endoleaks excluded) and reinterventions. Cox regression analysis was used to investigate whether any prespecified baseline factors were associated with time to first serious complication or reintervention. RESULTS: A total of 756 patients who had elective EVAR were followed for a mean of 3.7 years, by which time there were 179 serious graft complications (rate 6.5 per 100 person years) and 114 reinterventions (rate 3.8 per 100 person years). The highest rate was during the first 6 months, with an apparent increase again after 2 years. Multivariable analysis indicated that graft-related complications increased significantly with larger initial aneurysm diameter (P < 0.001) and older age (P = 0.040). There was also evidence that patients with larger common iliac diameters experienced higher complication rates (P = 0.011). CONCLUSION:Graft-related complication and reintervention rates were common after EVAR in patients with a large aneurysm. Younger patients and those with aneurysms closer to the 5.5-cm threshold for intervention experienced lower rates. Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
RCT Entities:
BACKGROUND: It is uncertain which baseline factors are associated with graft-related complications and reinterventions after endovascular aneurysm repair (EVAR) in patients with a large abdominal aortic aneurysm. METHODS:Patients randomized to elective EVAR in EVAR Trial 1 or 2 were followed for serious graft-related complications (type 2 endoleaks excluded) and reinterventions. Cox regression analysis was used to investigate whether any prespecified baseline factors were associated with time to first serious complication or reintervention. RESULTS: A total of 756 patients who had elective EVAR were followed for a mean of 3.7 years, by which time there were 179 serious graft complications (rate 6.5 per 100 person years) and 114 reinterventions (rate 3.8 per 100 person years). The highest rate was during the first 6 months, with an apparent increase again after 2 years. Multivariable analysis indicated that graft-related complications increased significantly with larger initial aneurysm diameter (P < 0.001) and older age (P = 0.040). There was also evidence that patients with larger common iliac diameters experienced higher complication rates (P = 0.011). CONCLUSION: Graft-related complication and reintervention rates were common after EVAR in patients with a large aneurysm. Younger patients and those with aneurysms closer to the 5.5-cm threshold for intervention experienced lower rates. Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Authors: Alan Karthikesalingam; Omneya Attallah; Xianghong Ma; Sandeep Singh Bahia; Luke Thompson; Alberto Vidal-Diez; Edward C Choke; Matt J Bown; Robert D Sayers; Matt M Thompson; Peter J Holt Journal: PLoS One Date: 2015-07-15 Impact factor: 3.240
Authors: I Grootes; J K Barrett; P Ulug; F Rohlffs; S J Laukontaus; R Tulamo; M Venermo; R M Greenhalgh; M J Sweeting Journal: Br J Surg Date: 2018-09 Impact factor: 6.939
Authors: Ulrika Asenbaum; Maria Schoder; Ernst Schwartz; Georg Langs; Pascal Baltzer; Florian Wolf; Alexander M Prusa; Christian Loewe; Richard Nolz Journal: Eur Radiol Date: 2019-06-27 Impact factor: 5.315
Authors: Omneya Attallah; Alan Karthikesalingam; Peter J E Holt; Matthew M Thompson; Rob Sayers; Matthew J Bown; Eddie C Choke; Xianghong Ma Journal: BMC Med Inform Decis Mak Date: 2017-08-03 Impact factor: 2.796