OBJECTIVE: To evaluate the geographic distribution of human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in the State of Minas Gerais, Brazil, in puerperal women whose newborns were tested for HTLV-1/2 during neonatal screening, and to overlap seropositivity with social and economic status determinants. METHODS: During September-November 2007, the dry-blood samples taken from newborns on filter paper for routine screening were also tested for maternal IgG anti-HTLV-1/2 antibodies. For reactive samples, the mothers of the newborns had blood drawn to test for these viruses. RESULTS: The study analyzed 55,293 specimens taken from newborns. Of these, 52 (9.4 per 10,000) were reactive and 42 mothers (7.6 per 10,000) were confirmed with HTLV-1/2 infection. HTLV-1/2 geographic distribution was heterogeneous, with a tendency to be higher in the North and North-East parts of Minas Gerais. The highest rates of seropositivity were observed in Vale do Mucuri (55.9 per 10,000) and in Jequitinhonha (16.0 per 10,000), overlapping with the State's worst social and economic indicators. CONCLUSIONS: To our knowledge this was the first time that neonatal screening for HTLV-1/2 was performed in Brazil. This model could be used in other areas with high HTLV-1/2 prevalence rates. The detection of carrier mothers can enable intervention measures, such as providing infant formula to newborns, to be implemented expeditiously to reduce vertical transmission.
OBJECTIVE: To evaluate the geographic distribution of human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in the State of Minas Gerais, Brazil, in puerperal women whose newborns were tested for HTLV-1/2 during neonatal screening, and to overlap seropositivity with social and economic status determinants. METHODS: During September-November 2007, the dry-blood samples taken from newborns on filter paper for routine screening were also tested for maternal IgG anti-HTLV-1/2 antibodies. For reactive samples, the mothers of the newborns had blood drawn to test for these viruses. RESULTS: The study analyzed 55,293 specimens taken from newborns. Of these, 52 (9.4 per 10,000) were reactive and 42 mothers (7.6 per 10,000) were confirmed with HTLV-1/2 infection. HTLV-1/2 geographic distribution was heterogeneous, with a tendency to be higher in the North and North-East parts of Minas Gerais. The highest rates of seropositivity were observed in Vale do Mucuri (55.9 per 10,000) and in Jequitinhonha (16.0 per 10,000), overlapping with the State's worst social and economic indicators. CONCLUSIONS: To our knowledge this was the first time that neonatal screening for HTLV-1/2 was performed in Brazil. This model could be used in other areas with high HTLV-1/2 prevalence rates. The detection of carrier mothers can enable intervention measures, such as providing infant formula to newborns, to be implemented expeditiously to reduce vertical transmission.
Authors: Maria de Fátima Castro Mendes; José de Ribamar Oliveira Lima; Bruna de Oliveira de Melo; Conceição de Maria Fernandes da Silva Pinto; Hermerson Sousa Maia; Thiago Azevedo Feitosa Ferro; Silvio Gomes Monteiro; Edel Figueiredo Barbosa Stancioli; Maria Rosa Quaresma Bomfim Journal: Braz J Microbiol Date: 2020-01-28 Impact factor: 2.476
Authors: Gabriela de Melo Franco; Anderson Santos da Rocha; Laura Jorge Cox; Danielle Soares de Oliveira Daian E Silva; Débora Marques da Silveira E Santos; Marina Lobato Martins; Luis Claudio Romanelli; Ricardo Ishak; Antonio C R Vallinoto; Maria Rosa Q Bomfim; Adele Caterino-de-Araujo; Jordana G A Coelho-Dos-Reis; Flávio Guimarães da Fonseca; Edel Figueiredo Barbosa-Stancioli Journal: Front Public Health Date: 2022-05-23
Authors: Denise Leite Maia Monteiro; Stella Regina Taquette; Danielle Bittencourt Sodré Barmpas; Nádia Cristina P Rodrigues; Sérgio A M Teixeira; Lucia Helena C Villela; Márcio Neves Bóia; Alexandre José Baptista Trajano Journal: PLoS Negl Trop Dis Date: 2014-09-04
Authors: María C Frutos; Rene Gastaldello; Marcos Balangero; Carlos Remondegui; Sebastián Blanco; Koko Otsuki; Ana Carolina Paulo Vicente; David Elías; Arnaldo Mangeaud; Silvia Nates; Sandra Gallego Journal: PLoS One Date: 2017-04-06 Impact factor: 3.240