| Literature DB >> 20601993 |
Sylvie Goncalves1, Paul Hellier, Marc Nicolas, Alain Wagner, Rachid Baati.
Abstract
A concise and diastereoselective formal total synthesis of triptolide, a natural product with a wide range of biological properties, is described. The key reaction is an unprecedented 6-endo-Trig cationic cyclization of a 2-alkenyl-1,3-dithiolane precursor induced by TMSOTf as Lewis acid.Entities:
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Year: 2010 PMID： 20601993 DOI： 10.1039/c0cc00250j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222