PURPOSE OF REVIEW: To examine the role of fluid therapy in the pathogenesis of severe sepsis and septic shock. The type, composition, titration, management strategies and complications of fluid administration will be examined in respect to outcomes. RECENT FINDINGS: Fluids have a critical role in the pathogenesis and treatment of early resuscitation of severe sepsis and septic shock. SUMMARY: Although this pathogenesis is evolving, early titrated fluid administration modulates inflammation, improves microvascular perfusion, impacts organ function and outcome. Fluid administration has limited impact on tissue perfusion during the later stages of sepsis and excess fluid is deleterious to outcome. The type of fluid solution does not seem to influence these observations.
PURPOSE OF REVIEW: To examine the role of fluid therapy in the pathogenesis of severe sepsis and septic shock. The type, composition, titration, management strategies and complications of fluid administration will be examined in respect to outcomes. RECENT FINDINGS: Fluids have a critical role in the pathogenesis and treatment of early resuscitation of severe sepsis and septic shock. SUMMARY: Although this pathogenesis is evolving, early titrated fluid administration modulates inflammation, improves microvascular perfusion, impacts organ function and outcome. Fluid administration has limited impact on tissue perfusion during the later stages of sepsis and excess fluid is deleterious to outcome. The type of fluid solution does not seem to influence these observations.
Authors: Samuel B Nguah; Torsten Feldt; Steffi Hoffmann; Daniel Pelletier; Daniel Ansong; Justice Sylverken; Parisa Mehrfar; Johanna Herr; Christian Thiel; Stephan Ehrhardt; Gerd D Burchard; Jakob P Cramer Journal: Intensive Care Med Date: 2012-08-14 Impact factor: 17.440
Authors: Javier A Neyra; Xilong Li; Fabrizio Canepa-Escaro; Beverley Adams-Huet; Robert D Toto; Jerry Yee; S Susan Hedayati Journal: Crit Care Med Date: 2016-10 Impact factor: 7.598
Authors: Johanna Herr; Parisa Mehrfar; Stefan Schmiedel; Dominic Wichmann; Norbert W Brattig; Gerd D Burchard; Jakob P Cramer Journal: Malar J Date: 2011-06-09 Impact factor: 2.979
Authors: Liam Byrne; Nchafatso G Obonyo; Sara D Diab; Kimble R Dunster; Margaret R Passmore; Ai-Ching Boon; Louise See Hoe; Sanne Pedersen; Mohd Hashairi Fauzi; Leticia Pretti Pimenta; Frank Van Haren; Christopher M Anstey; Louise Cullen; John-Paul Tung; Kiran Shekar; Kathryn Maitland; John F Fraser Journal: Am J Respir Crit Care Med Date: 2018-10-15 Impact factor: 30.528
Authors: Jean Charchaflieh; Jiandong Wei; Georges Labaze; Yunfang Joan Hou; Benjamin Babarsh; Helen Stutz; Haekyung Lee; Samrat Worah; Ming Zhang Journal: Clin Dev Immunol Date: 2012-09-23