Literature DB >> 2060085

Acetazolamide for alkalinisation of urine in patients receiving high-dose methotrexate.

J Shamash1, H Earl, R Souhami.   

Abstract

Acetazolamide, 500 mg 6 hourly, has been used to alkalinise the urine in patients receiving high dose methotrexate. A urinary pH of greater than 7.5 was achieved in every cycle (13 cycles in 10 patients). In 6 cycles a single supplementary dose of sodium bicarbonate was necessary. Plasma methotrexate levels fell satisfactorily at 24 and 48 h. Acetazolamide is a simple and effective method of achieving urinary alkalinisation with advantages over oral and intravenous bicarbonate.

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Year:  1991        PMID： 2060085     DOI： 10.1007/bf00689708

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  7 in total

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2.  The use of diamox in the sequential methotrexate-5-fluorouracil therapy of advanced gastrointestinal cancer.

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3.  MACOP-B chemotherapy for the treatment of diffuse large-cell lymphoma.

Authors:  P Klimo; J M Connors
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4.  Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma.

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5.  Severe renal toxicity due to intermediate-dose methotrexate.

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Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

Review 6.  The role of methotrexate in osteosarcoma.

Authors:  J L Grem; S A King; R E Wittes; B Leyland-Jones
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7.  The safety of administration of massive doses of methotrexate (50 g) with equimolar citrovorum factor rescue in adult patients.

Authors:  A Reggev; I Djerassi
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  7 in total
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Authors:  Scott C Howard; John McCormick; Ching-Hon Pui; Randall K Buddington; R Donald Harvey
Journal:  Oncologist       Date:  2016-08-05

3.  Evaluating the Effect of Acetazolamide on the Prevention of Post-operative Acute Kidney Injury after Coronary Artery Bypass Grafting Surgery: A Randomized, Open-labeled Clinical Trial.

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Journal:  Iran J Pharm Res       Date:  2021       Impact factor: 1.696

4.  A prospective study on urine alkalization with an oral regimen consisting of sodium bicarbonate and acetazolamide in patients receiving high-dose methotrexate.

Authors:  Daniel R Reed; Eric J Pierce; Jeremy M Sen; Michael K Keng
Journal:  Cancer Manag Res       Date:  2019-08-30       Impact factor: 3.989

5.  Acute Kidney Injury Following High-Dose Methotrexate Administration in a Day Care Hospital.

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  5 in total

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