Literature DB >> 20600791

Role of brominated diphenly ether-209 in the differentiation of neural stem cells in vitro.

Chunfang Zhang1, Xianbao Liu, Dunjin Chen.   

Abstract

Brominated diphenly ether-209 (BDE-209, decaBDE) is among the most common flame retardants. In a previous study, it was confirmed that exposure to BDE-209 can decrease learning and memory in mice. However, it is still unknown whether BDE-209 has an effect on cultured neural stem cells (NSCs). To analyse the role of BDE-209 in the differentiation of neural stem cells, NSCs obtained from neonatal rats were cultured as neurospheres in DMEM/F12 medium that contained different concentrations of BDE-209 for 7 days. BDE-209 was found to inhibit neurite outgrowth and the differentiation of NSCs into neurons in a concentration-dependent manner. BDE-209 also enhanced the ratio of differentiation of NSCs into glial cells. Copyright 2010 ISDN. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20600791     DOI： 10.1016/j.ijdevneu.2010.06.002

Source DB:  PubMed          Journal:  Int J Dev Neurosci        ISSN： 0736-5748            Impact factor:   2.457


  5 in total

Review 1.  Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?

Authors:  Lucio G Costa; Gennaro Giordano
Journal:  Neurotoxicology       Date:  2010-12-21       Impact factor: 4.294

Review 2.  Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.

Authors:  Jared J Schwartzer; Claire M Koenig; Robert F Berman
Journal:  Neurotoxicol Teratol       Date:  2012-09-07       Impact factor: 3.763

3.  The PBDE-209 exposure during pregnancy and lactation impairs immune function in rats.

Authors:  Xianbao Liu; Hong Zhan; Xu Zeng; Chunfang Zhang; Dunjin Chen
Journal:  Mediators Inflamm       Date:  2012-02-15       Impact factor: 4.711

Review 4.  Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system.

Authors:  Milou M L Dingemans; Martin van den Berg; Remco H S Westerink
Journal:  Environ Health Perspect       Date:  2011-02-04       Impact factor: 9.031

5.  Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation.

Authors:  Nichlas Davidsen; Anna Jacobsen Lauvås; Oddvar Myhre; Erik Ropstad; Donatella Carpi; Emilio Mendoza-de Gyves; Hanne Friis Berntsen; Hubert Dirven; Ragnhild E Paulsen; Anna Bal-Price; Francesca Pistollato
Journal:  Reprod Toxicol       Date:  2020-12-14       Impact factor: 3.143
  5 in total

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