| Literature DB >> 20600505 |
Catherine Hervouet1, Carmelo Luci, Nicolas Cuburu, Magali Cremel, Selma Bekri, Lene Vimeux, Concepcion Marañon, Cecil Czerkinsky, Anne Hosmalin, Fabienne Anjuère.
Abstract
A vaccine against heterosexual transmission by human immunodeficiency virus (HIV) should generate cytotoxic and antibody responses in the female genital tract and in extra-genital organs. We report that sublingual immunization with HIV-1 gp41 and a reverse transcriptase polypeptide coupled to the cholera toxin B subunit (CTB) induced gp41-specific IgA antibodies and antibody-secreting cells, as well as reverse transcriptase-specific CD8 T cells in the genital mucosa, contrary to intradermal immunization. Conjugation of the reverse transcriptase peptide to CTB favored its cross-presentation by human dendritic cells to a T cell line from an HIV(+) patient. Sublingual vaccination could represent a promising vaccine strategy against heterosexual transmission of HIV-1. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20600505 DOI： 10.1016/j.vaccine.2010.06.033
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641