Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia.

Literature DB >> 20600373

The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia.

Eiji Kitamura¹, Junichi Hamada, Naomi Kanazawa, Junko Yonekura, Ray Masuda, Fumihiko Sakai, Hideki Mochizuki.

Abstract

Orexin-A is a neuropeptide involved in the control feeding, arousal or sleep behavior in the hypothalamus. In the present study, the cortex and lateral hypothalamus of rats subjected to middle cerebral artery occlusion (MCAO)-reperfusion brain injury were examined by double immunofluorescence staining. The number of orexin-A-expressing neurons in the non-ischemic side was significantly lower than the ischemic side. Next, orexin-A was administered intracerebroventricularly followed by the induction of MCAO-reperfusion injury. Administration of orexin-A at 0.3nmol significantly reduced the brain infarct area. The results suggested that orexin-A alters the pathological mechanisms involved in brain ischemia and has a neuroprotective effect. 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20600373 DOI： 10.1016/j.neures.2010.06.010

Source DB: PubMed Journal: Neurosci Res ISSN： 0168-0102 Impact factor: 3.304

Keyword Cloud
Cited

22 in total

1. More Wake, Less Stroke.

Authors: Matteo Cerri
Journal: Sleep Date: 2015-11-01 Impact factor: 5.849

2. Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway.

Authors: Young-Jin Kang; Guilian Tian; Afsheen Bazrafkan; Maryam H Farahabadi; Matine Azadian; Hamidreza Abbasi; Brittany E Shamaoun; Oswald Steward; Yama Akbari
Journal: J Neurotrauma Date: 2017-06-16 Impact factor: 5.269

3. Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke.

Authors: Marta Pace; Francesca Baracchi; Bo Gao; Claudio Bassetti
Journal: Sleep Date: 2015-11-01 Impact factor: 5.849

Review 4. Exploring the Therapeutic Potential of Targeting Purinergic and Orexinergic Receptors in Alcoholic Neuropathy.

Authors: Piyush Madaan; Tapan Behl; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Shivam Yadav; Satvinder Kaur; Saurabh Bhatia; Ahmed Al-Harrasi; Ahmed A H Abdellatif; Ghulam Md Ashraf; Mohamed M Abdel-Daim; Hamad Ghaleb Dailah; Md Khalid Anwer; Simona Bungau
Journal: Neurotox Res Date: 2022-01-26 Impact factor: 3.911

The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia.

1. More Wake, Less Stroke.

2. Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway.

3. Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke.

Review 4. Exploring the Therapeutic Potential of Targeting Purinergic and Orexinergic Receptors in Alcoholic Neuropathy.

5. Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation.

Review 6. Intranasal insulin and orexins to treat age-related cognitive decline.

7. Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis.

Review 8. The role of orexin in post-stroke inflammation, cognitive decline, and depression.

9. Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells.

10. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.