Literature DB >> 20598537

Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus.

Keyur G Brahmbhatt1, Nafees Ahmed, Sudeep Sabde, Debashis Mitra, Inder Pal Singh, Kamlesh K Bhutani.   

Abstract

A series of beta-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL(4.3) virus. 1-Formyl-beta-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC(50)=2.9 microM. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20598537     DOI： 10.1016/j.bmcl.2010.06.052

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine.

Authors:  Jessica Baiget; Sabin Llona-Minguez; Stuart Lang; Simon P Mackay; Colin J Suckling; Oliver B Sutcliffe
Journal:  Beilstein J Org Chem       Date:  2011-10-12       Impact factor: 2.883

2.  1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes.

Authors:  Chongyang Wang; Ting Wang; Jiangkun Dai; Zhiyuan An; Ruochen Hu; Liuyuan Duan; Hui Chen; Xiangwei Wang; Zhili Chu; Haijin Liu; Juan Wang; Na Li; Zengqi Yang; Junru Wang
Journal:  Biomolecules       Date:  2021-11-12

3.  Design and Synthesis of Fluorescent 1,3-Diaryl-β-carbolines and 1,3-Diaryl-3,4-dihydro-β-carbolines.

Authors:  JiYang Pu; Biao Chen; Wanhua Wu; Cheng Yang; Guoqing Zhang; Jason J Chruma
Journal:  ACS Omega       Date:  2021-04-29

4.  Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids.

Authors:  Essmat M El-Sheref; Ashraf A Aly; Mohammed B Alshammari; Alan B Brown; Sara Mohamed Naguib Abdel-Hafez; Walaa Yehia Abdelzaher; Stefan Bräse; ElShimaa M N Abdelhafez
Journal:  Molecules       Date:  2020-10-30       Impact factor: 4.411
  4 in total

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