| Literature DB >> 20598535 |
Hiroaki Sasaki1, Kazuhiko Miki, Kaoru Kinoshita, Kiyotaka Koyama, Lia D Juliawaty, Sjamsul A Achmad, Euis H Hakim, Miyuki Kaneda, Kunio Takahashi.
Abstract
Here, we describe amentoflavone-type biflavonoids, which were isolated from natural sources and were found to inhibit beta-secretase (BACE-1). The structure-activity relationship was studied, and compounds 1-8, 10, 17, and 18 showed BACE-1 inhibitory activity. Among these compounds, 2,3-dihydroamentoflavone 17 and 2,3-dihydro-6-methylginkgetin 18 exhibited potent inhibitory effects with IC(50) values of 0.75 and 0.35 microM, respectively. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20598535 DOI： 10.1016/j.bmcl.2010.06.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823