| Literature DB >> 20598533 |
Qingmei Hong1, Raman K Bakshi, James Dellureficio, Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Rui Tang, Rubana N Kalyani, Tanya Macneil, Aurawan Vongs, Charles I Rosenblum, David H Weinberg, Qingping Peng, Constantin Tamvakopoulos, Randy R Miller, Ralph A Stearns, Doreen Cashen, Willian J Martin, Airu S Chen, Joseph M Metzger, Howard Y Chen, Allison M Strack, Tung M Fong, Euan Maclntyre, Lex H T Van der Ploeg, Matthew J Wyvratt, Ravi P Nargund.
Abstract
Design, syntheses and structure-activity relationships of N-acetylated piperazine privileged structures containing MC4R agonist compounds were described. The most potent derivatives were low nM MC4R selective full agonists. Several compounds from the series had modest pharmacokinetic properties. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20598533 DOI： 10.1016/j.bmcl.2010.06.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823