Literature DB >> 20598283

Adverse obstetric events are associated with significant risk of cerebral palsy.

William M Gilbert1, Bryon N Jacoby, Guibo Xing, Beate Danielsen, Lloyd H Smith.   

Abstract

OBJECTIVE: To examine adverse birth events on the development of cerebral palsy in California. STUDY
DESIGN: A retrospective population-based study of children with cerebral palsy (as of Nov. 30, 2006), matched to their maternal/infant delivery records (Jan. 1, 1991 to Dec. 31, 2001) was performed. Demographic data and intrapartum events were examined. Six adverse birth-related events were chosen. Children without cerebral palsy were controls.
RESULTS: There were 7242 children who had cerebral palsy (59% term) and 31.3% had 1 or more of the 6 adverse intrapartum events (12.9% in controls P < .0001). This held for both term (28.3% vs 12.7% controls) and preterm (36.8% vs 15.9%, controls) neonates (both P < .0001). Maternal (15.1% vs 6.6%) and neonatal (0.9% vs 0.1%) infection were increased in cerebral palsy cases (P < .0001).
CONCLUSION: Almost one-third of children with cerebral palsy had at least 1 adverse birth-related event. Higher rates in the preterm group may partially explain the higher rates of cerebral palsy in this group.
Copyright © 2010 Mosby, Inc. All rights reserved.

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Year:  2010        PMID: 20598283      PMCID: PMC2947602          DOI: 10.1016/j.ajog.2010.05.013

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN: 0002-9378            Impact factor:   8.661


  16 in total

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  5 in total

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4.  Systematic Review of Cerebral Palsy Registries/Surveillance Groups: Relationships between Registry Characteristics and Knowledge Dissemination.

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