J Salzer1, A Svenningsson, P Sundström. 1. Department of Neurology, Umeå University Hospital, Sweden. jonatan.salzer@neuro.umu.se <jonatan.salzer@neuro.umu.se>
Abstract
OBJECTIVE: To estimate the risk of multiple sclerosis (MS) by month of birth in Sweden. MATERIALS AND METHODS: Cases (n = 9361) were obtained from the Swedish MS Registry. All births in Sweden 1900-2007 served as controls (n = 12,116,853). The risk of MS was analyzed for each month of birth separately compared with birth during the other 11 months. RESULTS: More (11%) cases with MS than expected were born in June. Fewer (8% and 10%) cases with MS than expected were born in December and January (non-significant after correction for multiple analyses). More (5%) cases with MS than expected were born in February-July as compared with August-January. CONCLUSIONS: This study supports previous results suggesting an association between the risk of MS and the season of birth. Decreased exposure to sun in the winter leading to low vitamin D levels during pregnancy is a possible explanation that needs further research.
OBJECTIVE: To estimate the risk of multiple sclerosis (MS) by month of birth in Sweden. MATERIALS AND METHODS: Cases (n = 9361) were obtained from the Swedish MS Registry. All births in Sweden 1900-2007 served as controls (n = 12,116,853). The risk of MS was analyzed for each month of birth separately compared with birth during the other 11 months. RESULTS: More (11%) cases with MS than expected were born in June. Fewer (8% and 10%) cases with MS than expected were born in December and January (non-significant after correction for multiple analyses). More (5%) cases with MS than expected were born in February-July as compared with August-January. CONCLUSIONS: This study supports previous results suggesting an association between the risk of MS and the season of birth. Decreased exposure to sun in the winter leading to low vitamin D levels during pregnancy is a possible explanation that needs further research.
Authors: Fabrizio Salvi; Ilaria Bartolomei; Michael H Smolensky; Angelo Lorusso; Elena Barbarossa; Anna Maria Malagoni; Paolo Zamboni; Roberto Manfredini Journal: BMC Neurol Date: 2010-11-01 Impact factor: 2.474