| Literature DB >> 20596974 |
Hope H Wu1, Samiah Zafar, Youming Huan, Herman Yee, Luis Chiriboga, Beverly Y Wang.
Abstract
Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.Entities:
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Year: 2009 PMID： 20596974 PMCID： PMC2811625 DOI： 10.1007/s12105-009-0133-2
Source DB: PubMed Journal: Head Neck Pathol ISSN： 1936-055X