Literature DB >> 20596577

Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes.

Hidenobu Yaku1, Takashi Murashima, Daisuke Miyoshi, Naoki Sugimoto.   

Abstract

Anionic phthalocyanines inhibited efficiently telomerase activity even in the presence of excess double-stranded DNA (dsDNA) because of their selective binding to telomere G-quadruplex, although low selectivity of a typical cationic ligand, TMPyP4, to the G-quadruplex allowed telomerase reaction under conditions with dsDNA.

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Year:  2010        PMID： 20596577     DOI： 10.1039/c0cc00956c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Berberrubine Phosphate: A Selective Fluorescent Probe for Quadruplex DNA.

Authors:  Peter Jonas Wickhorst; Heiko Ihmels
Journal:  Molecules       Date:  2021-04-28       Impact factor: 4.411

2.  Use of a designed Peptide library to screen for binders to a particular DNA g-quadruplex sequence.

Authors:  Keita Kobayashi; Noriko Matsui; Kenji Usui
Journal:  J Nucleic Acids       Date:  2011-09-06

3.  The effects of molecular crowding on the structure and stability of g-quadruplexes with an abasic site.

Authors:  Takeshi Fujimoto; Shu-Ichi Nakano; Daisuke Miyoshi; Naoki Sugimoto
Journal:  J Nucleic Acids       Date:  2011-09-21

4.  A mRNA-Responsive G-Quadruplex-Based Drug Release System.

Authors:  Hidenobu Yaku; Takashi Murashima; Daisuke Miyoshi; Naoki Sugimoto
Journal:  Sensors (Basel)       Date:  2015-04-21       Impact factor: 3.576

5.  A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site.

Authors:  Ke-wei Zheng; Ren-yi Wu; Yi-de He; Shan Xiao; Jia-yu Zhang; Jia-quan Liu; Yu-hua Hao; Zheng Tan
Journal:  Nucleic Acids Res       Date:  2014-08-19       Impact factor: 16.971

6.  A highly sensitive telomerase activity assay that eliminates false-negative results caused by PCR inhibitors.

Authors:  Hidenobu Yaku; Takashi Murashima; Daisuke Miyoshi; Naoki Sugimoto
Journal:  Molecules       Date:  2013-09-25       Impact factor: 4.411

7.  Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control.

Authors:  Ke-wei Zheng; Shan Xiao; Jia-quan Liu; Jia-yu Zhang; Yu-hua Hao; Zheng Tan
Journal:  Nucleic Acids Res       Date:  2013-04-12       Impact factor: 16.971

8.  An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex.

Authors:  Keiko Kawauchi; Wataru Sugimoto; Takatoshi Yasui; Kohei Murata; Katsuhiko Itoh; Kazuki Takagi; Takaaki Tsuruoka; Kensuke Akamatsu; Hisae Tateishi-Karimata; Naoki Sugimoto; Daisuke Miyoshi
Journal:  Nat Commun       Date:  2018-06-11       Impact factor: 14.919

Review 9.  Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in vitro and in vivo applications.

Authors:  Hidenobu Yaku; Takashi Murashima; Daisuke Miyoshi; Naoki Sugimoto
Journal:  Molecules       Date:  2012-09-05       Impact factor: 4.411
  9 in total

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