BACKGROUND: Overweight and obesity are associated with an increased risk of acquiring type 2 diabetes and metabolic syndrome. We have assessed the prevalence of these conditions before and after gastric bypass surgery for morbid obesity. MATERIAL AND METHODS: The patients included had undergone laparoscopic gastric bypass at Oslo University Hospital Aker in the period 01.01.2007 - 31.12.2007 and had follow-up data for more than six months. Type 2 diabetes was defined as one or more of the following: an established diagnosis of diabetes before surgery, fasting plasma glucose >or= 7.0 mmol/l or HbA1c >or= 6.5 %. The metabolic syndrome was defined according to criteria laid out by the National Cholesterol Education Program. RESULTS: 136 patients (79 % women) with a mean (+/- SD) age of 43 +/- 9 years were included. Mean follow-up time was 17 months (range 8 - 26). The patients' body mass index (kg/m2) was reduced from 47 +/- 6 before to 32 +/- 6 after surgery (p<0.001). 34 % of patients had type 2 diabetes before and 10 % after surgery (p < 0.001). 80 % of patients had metabolic syndrome before and 24 % after surgery (p < 0.001). Fasting plasma glucose, HbA1c, and all variables included in the definition of metabolic syndrome were statistically significantly improved after surgery. INTERPRETATION: Gastric bypass has favourable effects on type 2 diabetes. Blood glucose normalised in most patients after the operation. The prevalence of metabolic syndrome was significantly lower after surgery.
BACKGROUND: Overweight and obesity are associated with an increased risk of acquiring type 2 diabetes and metabolic syndrome. We have assessed the prevalence of these conditions before and after gastric bypass surgery for morbid obesity. MATERIAL AND METHODS: The patients included had undergone laparoscopic gastric bypass at Oslo University Hospital Aker in the period 01.01.2007 - 31.12.2007 and had follow-up data for more than six months. Type 2 diabetes was defined as one or more of the following: an established diagnosis of diabetes before surgery, fasting plasma glucose >or= 7.0 mmol/l or HbA1c >or= 6.5 %. The metabolic syndrome was defined according to criteria laid out by the National Cholesterol Education Program. RESULTS: 136 patients (79 % women) with a mean (+/- SD) age of 43 +/- 9 years were included. Mean follow-up time was 17 months (range 8 - 26). The patients' body mass index (kg/m2) was reduced from 47 +/- 6 before to 32 +/- 6 after surgery (p<0.001). 34 % of patients had type 2 diabetes before and 10 % after surgery (p < 0.001). 80 % of patients had metabolic syndrome before and 24 % after surgery (p < 0.001). Fasting plasma glucose, HbA1c, and all variables included in the definition of metabolic syndrome were statistically significantly improved after surgery. INTERPRETATION: Gastric bypass has favourable effects on type 2 diabetes. Blood glucose normalised in most patients after the operation. The prevalence of metabolic syndrome was significantly lower after surgery.
Authors: Wiebke K Fenske; Dimitri J Pournaras; Erlend T Aasheim; Alexander D Miras; Nicola Scopinaro; Samantha Scholtz; Carel W le Roux Journal: Obes Surg Date: 2012-01 Impact factor: 4.129