OBJECTIVES: We hypothesized that fetal ventricular diastolic filling characteristics are related to fetal heart rate (FHR) and pulmonary vascular impedance. METHODS: Rhesus monkeys underwent Doppler ultrasonography at near-term gestation. Tricuspid (TV) and mitral valve (MV) blood velocity waveforms were used to calculate maximum velocity (V-max) and velocity time integral (VTI) E/A ratios (early filling/ventricular filling during atrial contraction) at baseline and during maternal hyperoxygenation. Right pulmonary artery (RPA) pulsatility indices (PIs) and FHR were measured. RESULTS: Hyperoxgenation significantly decreased FHR and RPA PI. The TV V-max and the MV VTI E/A ratios increased significantly and correlated with a decrease in FHR but not with a decrease in RPA PI. The TV and MV A-wave V-max decreased during hyperoxygenation and their decrease correlated significantly with a drop in FHR. CONCLUSIONS: Fetal ventricular diastolic filling characteristics are related to FHR but not to pulmonary vascular impedance.
OBJECTIVES: We hypothesized that fetal ventricular diastolic filling characteristics are related to fetal heart rate (FHR) and pulmonary vascular impedance. METHODS:Rhesus monkeys underwent Doppler ultrasonography at near-term gestation. Tricuspid (TV) and mitral valve (MV) blood velocity waveforms were used to calculate maximum velocity (V-max) and velocity time integral (VTI) E/A ratios (early filling/ventricular filling during atrial contraction) at baseline and during maternal hyperoxygenation. Right pulmonary artery (RPA) pulsatility indices (PIs) and FHR were measured. RESULTS: Hyperoxgenation significantly decreased FHR and RPA PI. The TV V-max and the MV VTI E/A ratios increased significantly and correlated with a decrease in FHR but not with a decrease in RPA PI. The TV and MV A-wave V-max decreased during hyperoxygenation and their decrease correlated significantly with a drop in FHR. CONCLUSIONS:Fetal ventricular diastolic filling characteristics are related to FHR but not to pulmonary vascular impedance.
Authors: Alec J Hirsch; Victoria H J Roberts; Peta L Grigsby; Nicole Haese; Matthias C Schabel; Xiaojie Wang; Jamie O Lo; Zheng Liu; Christopher D Kroenke; Jessica L Smith; Meredith Kelleher; Rebecca Broeckel; Craig N Kreklywich; Christopher J Parkins; Michael Denton; Patricia Smith; Victor DeFilippis; William Messer; Jay A Nelson; Jon D Hennebold; Marjorie Grafe; Lois Colgin; Anne Lewis; Rebecca Ducore; Tonya Swanson; Alfred W Legasse; Michael K Axthelm; Rhonda MacAllister; Ashlee V Moses; Terry K Morgan; Antonio E Frias; Daniel N Streblow Journal: Nat Commun Date: 2018-01-17 Impact factor: 14.919