Literature DB >> 20594837

Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives.

Santosh N Mokale1, Sandeep S Shinde, Rupali D Elgire, Jaiprakash N Sangshetti, Devanand B Shinde.   

Abstract

A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p <0.05) anti-inflammatory activity. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20594837     DOI： 10.1016/j.bmcl.2010.06.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Development of energetic pharmacophore for the designing of 1,2,3,4-tetrahydropyrimidine derivatives as selective cyclooxygenase-2 inhibitors.

Authors:  Deepak Lokwani; Reecha Shah; Santosh Mokale; Padma Shastry; Devanand Shinde
Journal:  J Comput Aided Mol Des       Date:  2012-01-05       Impact factor: 3.686

2.  Synthesis and antitumoral activity of novel analogues monastrol-fatty acids against glioma cells.

Authors:  Franciele S De Oliveira; Patrick M De Oliveira; Luana M Farias; Rafael C Brinkerhoff; Rui Carlos M A Sobrinho; Tamara M Treptow; Caroline R Montes D'Oca; Marcelo A G Marinho; Mariana A Hort; Ana P Horn; Dennis Russowsky; Marcelo G Montes D'Oca
Journal:  Medchemcomm       Date:  2018-05-30       Impact factor: 3.597

Review 3.  Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions.

Authors:  Ingrid V Machado; Jhonathan R N Dos Santos; Marcelo A P Januario; Arlene G Corrêa
Journal:  Ultrason Sonochem       Date:  2021-08-05       Impact factor: 7.491

4.  One-pot synthesis, X-ray crystal structure, and identification of potential molecules against COVID-19 main protease through structure-guided modeling and simulation approach.

Authors:  Youness El Bakri; Malahat Musrat Kurbanova; Sabir Ali Siddique; Sajjad Ahmad; Souraya Goumri-Said
Journal:  Arab J Chem       Date:  2022-09-15       Impact factor: 6.212

5.  Monastrol derivatives: in silico and in vitro cytotoxicity assessments.

Authors:  Zahra Bidram; Hajar Sirous; Ghadam Ali Khodarahmi; Farshid Hassanzadeh; Nasim Dana; Amir Ali Hariri; Mahboubeh Rostami
Journal:  Res Pharm Sci       Date:  2020-07-03

6.  Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

Authors:  Alakbar E Huseynzada; Christian Jelch; Haji Vahid N Akhundzada; Sarra Soudani; Cherif Ben Nasr; Aygun Israyilova; Filippo Doria; Ulviyya A Hasanova; Rana F Khankishiyeva; Mauro Freccero
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

Review 7.  Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions.

Authors:  Francisco Sánchez-Sancho; Marcos Escolano; Daniel Gaviña; Aurelio G Csáky; María Sánchez-Roselló; Santiago Díaz-Oltra; Carlos Del Pozo
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-30

Review 8.  A mini-review on Biginelli adducts with notable pharmacological properties.

Authors:  Ângelo de Fátima; Taniris C Braga; Leonardo da S Neto; Bruna S Terra; Breno G F Oliveira; Daniel L da Silva; Luzia V Modolo
Journal:  J Adv Res       Date:  2014-11-01       Impact factor: 10.479

9.  FeCl₃∙6H₂O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation.

Authors:  Fei Zhao; Xiuwen Jia; Pinyi Li; Jingwei Zhao; Jun Huang; Honglian Li; Lin Li
Journal:  Molecules       Date:  2017-09-11       Impact factor: 4.411
  9 in total

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