Literature DB >> 20594592

Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia.

Carlos A Tirado1, Weina Chen, Lily Jun-shen Huang, Carrie Laborde, Matthew C Hiemenz, Federico Valdez, Kevin Ho, Naomi Winick, Zhenjun Lou, Prasad Koduru.   

Abstract

Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20594592     DOI： 10.1016/j.leukres.2010.05.031

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  10 in total

Review 1.  Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature.

Authors:  Bulent Kantarcioglu; Isik Kaygusuz-Atagunduz; Ant Uzay; Tayfur Toptas; Tulin Firatli Tuglular; Mahmut Bayik
Journal:  Int J Hematol       Date:  2015-04-02       Impact factor: 2.490

Review 2.  A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken.

Authors:  K Gnanasambandan; P P Sayeski
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

Review 3.  Philadelphia chromosome-like acute lymphoblastic leukemia.

Authors:  Sarah K Tasian; Mignon L Loh; Stephen P Hunger
Journal:  Blood       Date:  2017-10-02       Impact factor: 22.113

4.  Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene.

Authors:  Marcelo Bellesso; Rodrigo Santucci; Daniela Ferreira Dias; Renato Centrone; Renata Campos Elias
Journal:  Rev Bras Hematol Hemoter       Date:  2013

5.  Transformation of an Unclassified Myeloproliferative Neoplasm with a Rare BCR-JAK2 Fusion Transcript Resulting from the Translocation (9;22)(p24;q11).

Authors:  A N Chamseddine; P Etancelin; D Penther; F Parmentier; C Kuadjovi; V Camus; N Contentin; P Lenain; C Bastard; H Tilly; F Jardin
Journal:  Case Rep Hematol       Date:  2015-02-18

Review 6.  Childhood B-acute lymphoblastic leukemia: a genetic update.

Authors:  Jennifer S Woo; Michael O Alberti; Carlos A Tirado
Journal:  Exp Hematol Oncol       Date:  2014-06-13

7.  JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia.

Authors:  Elisabeth M P Steeghs; Isabel S Jerchel; Willemieke de Goffau-Nobel; Alex Q Hoogkamer; Judith M Boer; Aurélie Boeree; Cesca van de Ven; Marco J Koudijs; Nicolle J M Besselink; Hester A de Groot-Kruseman; Christian Michel Zwaan; Martin A Horstmann; Rob Pieters; Monique L den Boer
Journal:  Oncotarget       Date:  2017-09-16

8.  Identification of RNPC3 as a novel JAK2 fusion partner gene in B-acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib.

Authors:  Xue Chen; Fang Wang; Yang Zhang; Xiaoli Ma; Mingyue Liu; Panxiang Cao; Lin Zhou; Lan Wang; Xian Zhang; Tong Wang; Hongxing Liu
Journal:  Mol Genet Genomic Med       Date:  2019-12-30       Impact factor: 2.183

9.  Haemophagocytic syndrome triggered by acute lymphoblastic leukaemia with t(9;22)(p24; q11.2).

Authors:  Huiling Chen; Pengyun Zeng; Dekui Zhang
Journal:  J Int Med Res       Date:  2019-09-18       Impact factor: 1.671

10.  A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27.

Authors:  David Shabsovich; Matthew DeNicola; Carlos A Tirado; Dinesh Rao; Lynn Yang; Rolando Garcia; Nagesh Rao
Journal:  Biomark Res       Date:  2013-11-25
  10 in total

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