Literature DB >> 20593215

Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes.

Surya Pavan Yenamandra1, Ulf Hellman, Bettina Kempkes, Suhas Deoram Darekar, Sabine Petermann, Tom Sculley, George Klein, Elena Kashuba.   

Abstract

Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.

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Year:  2010        PMID： 20593215     DOI： 10.1007/s00018-010-0441-4

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  31 in total

1.  Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis.

Authors:  Jae Myun Lee; Kyoung-Ho Lee; Magdalena Weidner; Barbara A Osborne; S Diane Hayward
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-23       Impact factor: 11.205

2.  EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli.

Authors:  Jae Myun Lee; Kyoung-Ho Lee; Christopher J Farrell; Paul D Ling; Bettina Kempkes; Jeon Han Park; S Diane Hayward
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

3.  Multiple functions within the Epstein-Barr virus EBNA-3A protein.

Authors:  I Cludts; P J Farrell
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103

4.  Epstein-Barr nuclear antigen-3 and -4 interact with RBP-2N, a major isoform of RBP-J kappa in B lymphocytes.

Authors:  K G Krauer; N Kienzle; D B Young; T B Sculley
Journal:  Virology       Date:  1996-12-15       Impact factor: 3.616

5.  Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein.

Authors:  Elena V Kashuba; Katarina Gradin; Marja Isaguliants; Laszlo Szekely; Lorenz Poellinger; George Klein; Arunas Kazlauskas
Journal:  J Biol Chem       Date:  2005-10-28       Impact factor: 5.157

6.  Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa.

Authors:  E S Robertson; S Grossman; E Johannsen; C Miller; J Lin; B Tomkinson; E Kieff
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

7.  Vitamin D-mediated gene regulation in phenotypically defined human B cell subpopulations.

Authors:  J W Morgan; N Kouttab; D Ford; A L Maizel
Journal:  Endocrinology       Date:  2000-09       Impact factor: 4.736

8.  The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.

Authors:  Hirochika Kitagawa; Ryoji Fujiki; Kimihiro Yoshimura; Yoshihiro Mezaki; Yoshikatsu Uematsu; Daisuke Matsui; Satoko Ogawa; Kiyoe Unno; Mataichi Okubo; Akifumi Tokita; Takeya Nakagawa; Takashi Ito; Yukio Ishimi; Hiromichi Nagasawa; Toshio Matsumoto; Junn Yanagisawa; Shigeaki Kato
Journal:  Cell       Date:  2003-06-27       Impact factor: 41.582

9.  Epstein-Barr virus antagonizes the antiproliferative activity of transforming growth factor-beta but does not abolish its signaling.

Authors:  Manuela Horndasch; Eva E Raschke; Guido Bommer; Marino Schuhmacher; Elisabeth Dumont; Conny Kuklik-Roos; Dirk Eick; Bettina Kempkes
Journal:  Int J Cancer       Date:  2002-10-10       Impact factor: 7.396

10.  Expression profile of nuclear receptors upon Epstein -- Barr virus induced B cell transformation.

Authors:  S P Yenamandra; A Lundin; V Arulampalam; M Yurchenko; S Pettersson; G Klein; E Kashuba
Journal:  Exp Oncol       Date:  2009-06
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  13 in total

1.  Antimicrobial implications of vitamin D.

Authors:  Dima A Youssef; Christopher Wt Miller; Adel M El-Abbassi; Della C Cutchins; Coleman Cutchins; William B Grant; Alan N Peiris
Journal:  Dermatoendocrinol       Date:  2011-10-01

2.  Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma.

Authors:  Christoph Renné; Alexander H Benz; Martin L Hansmann
Journal:  BMC Cancer       Date:  2012-06-06       Impact factor: 4.430

3.  EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.

Authors:  Vito A G Ricigliano; Adam E Handel; Geir K Sandve; Viviana Annibali; Giovanni Ristori; Rosella Mechelli; M Zameel Cader; Marco Salvetti
Journal:  PLoS One       Date:  2015-04-08       Impact factor: 3.240

4.  Evolutionary Origin of the Interferon-Immune Metabolic Axis: The Sterol-Vitamin D Link.

Authors:  Harry Newmark; Widad Dantoft; Peter Ghazal
Journal:  Front Immunol       Date:  2017-02-09       Impact factor: 7.561

5.  Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.

Authors:  Muhammad Mushtaq; Larysa Kovalevska; Suhas Darekar; Alexandra Abramsson; Henrik Zetterberg; Vladimir Kashuba; George Klein; Marie Arsenian-Henriksson; Elena Kashuba
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-22       Impact factor: 11.205

Review 6.  A Brief Review of the Effects of Vitamin D on Multiple Sclerosis.

Authors:  Andrei Miclea; Maud Bagnoud; Andrew Chan; Robert Hoepner
Journal:  Front Immunol       Date:  2020-05-06       Impact factor: 7.561

Review 7.  Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms.

Authors:  Amy D Proal; Michael B VanElzakker
Journal:  Front Microbiol       Date:  2021-06-23       Impact factor: 5.640

8.  Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect.

Authors:  Suhas Darekar; Konstantinos Georgiou; Mariya Yurchenko; Surya Pavan Yenamandra; Georgia Chachami; George Simos; George Klein; Elena Kashuba
Journal:  PLoS One       Date:  2012-07-27       Impact factor: 3.240

Review 9.  Glia in the cytokine-mediated onset of depression: fine tuning the immune response.

Authors:  Wendy K Jo; Yuanyuan Zhang; Hinderk M Emrich; Detlef E Dietrich
Journal:  Front Cell Neurosci       Date:  2015-07-10       Impact factor: 5.505

10.  Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.

Authors:  Quentin Bazot; Thibaut Deschamps; Lionel Tafforeau; Maha Siouda; Pascal Leblanc; Marie L Harth-Hertle; Chantal Rabourdin-Combe; Vincent Lotteau; Bettina Kempkes; Massimo Tommasino; Henri Gruffat; Evelyne Manet
Journal:  Nucleic Acids Res       Date:  2014-08-04       Impact factor: 16.971
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