Literature DB >> 20592261

Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.

Surendra S Ambegaokar1, George R Jackson.   

Abstract

Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205.

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Year:  2010        PMID： 20592261      PMCID： PMC2940309          DOI： 10.1534/genetics.110.119545

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  60 in total

1.  Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster.

Authors:  S M Mackenzie; A J Howells; G B Cox; G D Ewart
Journal:  Genetica       Date:  2000       Impact factor: 1.082

2.  Cloning and characterization of the scarlet gene of Drosophila melanogaster.

Authors:  R G Tearle; J M Belote; M McKeown; B S Baker; A J Howells
Journal:  Genetics       Date:  1989-07       Impact factor: 4.562

3.  Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

Authors:  G T Bramblett; M Goedert; R Jakes; S E Merrick; J Q Trojanowski; V M Lee
Journal:  Neuron       Date:  1993-06       Impact factor: 17.173

4.  Xanthine oxidoreductase gene expression and enzyme activity in developing human tissues.

Authors:  M Saksela; R Lapatto; K O Raivio
Journal:  Biol Neonate       Date:  1998-10

5.  The rosy locus in Drosophila melanogaster: xanthine dehydrogenase and eye pigments.

Authors:  A G Reaume; D A Knecht; A Chovnick
Journal:  Genetics       Date:  1991-12       Impact factor: 4.562

6.  Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

Authors:  E M Mandelkow; G Drewes; J Biernat; N Gustke; J Van Lint; J R Vandenheede; E Mandelkow
Journal:  FEBS Lett       Date:  1992-12-21       Impact factor: 4.124

7.  Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

Authors:  H K Paudel; J Lew; Z Ali; J H Wang
Journal:  J Biol Chem       Date:  1993-11-05       Impact factor: 5.157

8.  Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene.

Authors:  K Ichida; Y Amaya; K Noda; S Minoshima; T Hosoya; O Sakai; N Shimizu; T Nishino
Journal:  Gene       Date:  1993-11-15       Impact factor: 3.688

9.  Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

Authors:  G Drewes; B Lichtenberg-Kraag; F Döring; E M Mandelkow; J Biernat; J Goris; M Dorée; E Mandelkow
Journal:  EMBO J       Date:  1992-06       Impact factor: 11.598

10.  The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

Authors:  J Biernat; E M Mandelkow; C Schröter; B Lichtenberg-Kraag; B Steiner; B Berling; H Meyer; M Mercken; A Vandermeeren; M Goedert; E Mandelkow
Journal:  EMBO J       Date:  1992-04       Impact factor: 11.598
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  10 in total

1.  Double vision: pigment genes do more than just color.

Authors:  Surendra S Ambegaokar; George Jackson
Journal:  Fly (Austin)       Date:  2011-07-01       Impact factor: 2.160

2.  Neurodegeneration and locomotor dysfunction in Drosophila scarlet mutants.

Authors:  Patrick C Cunningham; Katherine Waldeck; Barry Ganetzky; Daniel T Babcock
Journal:  J Cell Sci       Date:  2018-09-17       Impact factor: 5.285

Review 3.  Drosophila as an In Vivo Model for Human Neurodegenerative Disease.

Authors:  Leeanne McGurk; Amit Berson; Nancy M Bonini
Journal:  Genetics       Date:  2015-10       Impact factor: 4.562

4.  Drosophila strain specific response to cisplatin neurotoxicity.

Authors:  Christopher M Groen; Jewel L Podratz; Kevin Treb; Anthony J Windebank
Journal:  Fly (Austin)       Date:  2019-01-22       Impact factor: 2.160

5.  Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.

Authors:  Surendra S Ambegaokar; George R Jackson
Journal:  Hum Mol Genet       Date:  2011-09-23       Impact factor: 6.150

6.  Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes.

Authors:  Patrick J Wightman; George R Jackson; Katrina M Dipple
Journal:  PLoS One       Date:  2012-03-09       Impact factor: 3.240

7.  Drosophila models of tauopathies: what have we learned?

Authors:  Marc Gistelinck; Jean-Charles Lambert; Patrick Callaerts; Bart Dermaut; Pierre Dourlen
Journal:  Int J Alzheimers Dis       Date:  2012-06-04

8.  Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration.

Authors:  María José Ferreiro; Coralia Pérez; Mariana Marchesano; Santiago Ruiz; Angel Caputi; Pedro Aguilera; Rosa Barrio; Rafael Cantera
Journal:  Front Neurosci       Date:  2018-01-04       Impact factor: 4.677

9.  Genetic human prion disease modelled in PrP transgenic Drosophila.

Authors:  Alana M Thackray; Alzbeta Cardova; Hanna Wolf; Lydia Pradl; Ina Vorberg; Walker S Jackson; Raymond Bujdoso
Journal:  Biochem J       Date:  2017-09-20       Impact factor: 3.857

10.  Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.

Authors:  Bidisha Roy; George R Jackson
Journal:  Hum Mol Genet       Date:  2014-01-14       Impact factor: 5.121
  10 in total

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