Literature DB >> 20591666

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

Sonia Gattinoni1, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Natalia Battista, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini, Mauro Maccarrone.   

Abstract

A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20591666     DOI： 10.1016/j.bmcl.2010.06.050

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.

Authors:  Federica Vacondio; Claudia Silva; Alessio Lodola; Caterina Carmi; Silvia Rivara; Andrea Duranti; Andrea Tontini; Silvano Sanchini; Jason R Clapper; Daniele Piomelli; Giorgio Tarzia; Marco Mor
Journal:  Eur J Med Chem       Date:  2011-07-21       Impact factor: 6.514

2.  Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor.

Authors:  Mariangela Pucci; Nicoletta Pasquariello; Natalia Battista; Monia Di Tommaso; Cinzia Rapino; Filomena Fezza; Michela Zuccolo; Roland Jourdain; Alessandro Finazzi Agrò; Lionel Breton; Mauro Maccarrone
Journal:  J Biol Chem       Date:  2012-03-19       Impact factor: 5.157

Review 3.  The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Authors:  Katerina Otrubova; Cyrine Ezzili; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2011-06-28       Impact factor: 2.823

Review 4.  Chemical probes of endocannabinoid metabolism.

Authors:  Jacqueline L Blankman; Benjamin F Cravatt
Journal:  Pharmacol Rev       Date:  2013-03-19       Impact factor: 25.468

Review 5.  Organic carbamates in drug design and medicinal chemistry.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  J Med Chem       Date:  2015-01-07       Impact factor: 7.446

6.  p-Pyridinyl oxime carbamates: synthesis, DNA binding, DNA photocleaving activity and theoretical photodegradation studies.

Authors:  Panagiotis S Gritzapis; Panayiotis C Varras; Nikolaos-Panagiotis Andreou; Katerina R Katsani; Konstantinos Dafnopoulos; George Psomas; Zisis V Peitsinis; Alexandros E Koumbis; Konstantina C Fylaktakidou
Journal:  Beilstein J Org Chem       Date:  2020-03-09       Impact factor: 2.883

7.  Dissociation or cyclization: options for a triad of radicals released from oxime carbamates.

Authors:  Roy T McBurney; John C Walton
Journal:  J Am Chem Soc       Date:  2013-05-01       Impact factor: 15.419

8.  Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety.

Authors:  Eva M Marco; Cinzia Rapino; Antonio Caprioli; Franco Borsini; Giovanni Laviola; Mauro Maccarrone
Journal:  PLoS One       Date:  2015-09-11       Impact factor: 3.240
  8 in total

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