PURPOSE: To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). DESIGN: Retrospective, observational case series. METHODS: Thirty-four eyes (34 subjects), with no retinal or choroidal disease, underwent high-definition raster scanning using SD-OCT with frame enhancement software. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-microm intervals up to 2500 microm temporal and nasal to the fovea. The central 1-mm area of the choroid was also measured, along with foveal thickness of the retina. All measurements were performed by 2 independent observers. Statistical analysis was used to correlate inter-observer findings, choroidal thickness and area measurements with age, and choroidal thickness with retinal foveal thickness. RESULTS: The 34 subjects had a mean age of 51.1 years. Reliable measurements of choroidal thickness were obtainable in 74% of eyes examined. Choroidal thickness and area measurements had strong inter-observer correlation (r = 0.92, P < .0001 and r = 0.93, P < .0001 respectively). Area had a moderate negative correlation with age (r = -0.62, P < .0001) that was comparable to the correlation between mean subfoveal choroidal thickness and age (r = -0.61, P < .0001). Retinal and choroidal thickness were found to be poorly correlated (r = -0.23, P = .18). Mean choroidal thickness showed a pattern of thinnest choroid nasally, thickening in the subfoveal region, and then thinning again temporally. Mean subfoveal choroidal thickness was found to be 272 microm (SD, +/- 81 microm). CONCLUSIONS: Choroidal thickness can be measured using SD-OCT high-definition raster scans in the majority of eyes. Choroidal thickness across the macula demonstrates a thin choroid nasally, thickest subfoveally, and again thinner temporally, and a trend toward decreasing choroidal thickness with age. Copyright (c) 2010 Elsevier Inc. All rights reserved.
PURPOSE: To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). DESIGN: Retrospective, observational case series. METHODS: Thirty-four eyes (34 subjects), with no retinal or choroidal disease, underwent high-definition raster scanning using SD-OCT with frame enhancement software. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-microm intervals up to 2500 microm temporal and nasal to the fovea. The central 1-mm area of the choroid was also measured, along with foveal thickness of the retina. All measurements were performed by 2 independent observers. Statistical analysis was used to correlate inter-observer findings, choroidal thickness and area measurements with age, and choroidal thickness with retinal foveal thickness. RESULTS: The 34 subjects had a mean age of 51.1 years. Reliable measurements of choroidal thickness were obtainable in 74% of eyes examined. Choroidal thickness and area measurements had strong inter-observer correlation (r = 0.92, P < .0001 and r = 0.93, P < .0001 respectively). Area had a moderate negative correlation with age (r = -0.62, P < .0001) that was comparable to the correlation between mean subfoveal choroidal thickness and age (r = -0.61, P < .0001). Retinal and choroidal thickness were found to be poorly correlated (r = -0.23, P = .18). Mean choroidal thickness showed a pattern of thinnest choroid nasally, thickening in the subfoveal region, and then thinning again temporally. Mean subfoveal choroidal thickness was found to be 272 microm (SD, +/- 81 microm). CONCLUSIONS: Choroidal thickness can be measured using SD-OCT high-definition raster scans in the majority of eyes. Choroidal thickness across the macula demonstrates a thin choroid nasally, thickest subfoveally, and again thinner temporally, and a trend toward decreasing choroidal thickness with age. Copyright (c) 2010 Elsevier Inc. All rights reserved.
Authors: Elisabeth M Anger; Angelika Unterhuber; Boris Hermann; Harald Sattmann; Christian Schubert; James E Morgan; Alan Cowey; Peter K Ahnelt; Wolfgang Drexler Journal: Exp Eye Res Date: 2004-06 Impact factor: 3.467
Authors: R Daniel Ferguson; Daniel X Hammer; Lelia Adelina Paunescu; Siobahn Beaton; Joel S Schuman Journal: Opt Lett Date: 2004-09-15 Impact factor: 3.776
Authors: Takamitsu Fujiwara; Yutaka Imamura; Ron Margolis; Jason S Slakter; Richard F Spaide Journal: Am J Ophthalmol Date: 2009-07-09 Impact factor: 5.258
Authors: D Huang; E A Swanson; C P Lin; J S Schuman; W G Stinson; W Chang; M R Hee; T Flotte; K Gregory; C A Puliafito Journal: Science Date: 1991-11-22 Impact factor: 47.728
Authors: Boris Povazay; Boris Hermann; Angelika Unterhuber; Bernd Hofer; Harald Sattmann; Florian Zeiler; James E Morgan; Christiane Falkner-Radler; Carl Glittenberg; Susanne Blinder; Wolfgang Drexler Journal: J Biomed Opt Date: 2007 Jul-Aug Impact factor: 3.170
Authors: Teresa C Chen; Barry Cense; Joan W Miller; Peter A D Rubin; Daniel G Deschler; Evangelos S Gragoudas; Johannes F de Boer Journal: Am J Ophthalmol Date: 2006-06 Impact factor: 5.258
Authors: Kathrin J Mohler; Wolfgang Draxinger; Thomas Klein; Jan Philip Kolb; Wolfgang Wieser; Christos Haritoglou; Anselm Kampik; James G Fujimoto; Aljoscha S Neubauer; Robert Huber; Armin Wolf Journal: Invest Ophthalmol Vis Sci Date: 2015-10 Impact factor: 4.799
Authors: Yuchun Tsai; Bin Lu; Alexander V Ljubimov; Sergey Girman; Fred N Ross-Cisneros; Alfredo A Sadun; Clive N Svendsen; Robert M Cohen; Shaomei Wang Journal: Invest Ophthalmol Vis Sci Date: 2014-01-29 Impact factor: 4.799
Authors: Yanling Ouyang; Florian M Heussen; Nils Mokwa; Alexander C Walsh; Mary K Durbin; Pearse A Keane; P James Sanchez; Humberto Ruiz-Garcia; Srinivas R Sadda Journal: Invest Ophthalmol Vis Sci Date: 2011-09-01 Impact factor: 4.799
Authors: Li Zhang; Kyungmoo Lee; Meindert Niemeijer; Robert F Mullins; Milan Sonka; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2012-11-01 Impact factor: 4.799