Literature DB >> 20590620

The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle.

M A Hollywood1, G P Sergeant, K D Thornbury, N G McHale.   

Abstract

In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U-73122 can potently inhibit Ca(2+) release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the sarcoplasmic/endoplasmic reticulum calcium ATPase pump in smooth muscle and cast doubt on the reliability of U-73122 as the main pharmacological tool to assess the role of the phosphotidyl inositol-PLC pathway in cellular signalling.

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Year:  2010        PMID： 20590620      PMCID： PMC2938801          DOI： 10.1111/j.1476-5381.2010.00795.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

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