Literature DB >> 20589309

An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance.

Xuli Feng1, Libing Liu, Xinrui Duan, Shu Wang.   

Abstract

Synthetic riboswitch containing aptamer is constructed in E. coli to regulate the expression of β-lactamase through small molecule-aptamer interactions, which sharply reduces the antibiotic resistance of the engineered bacteria.

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Year:  2010        PMID： 20589309     DOI： 10.1039/c0cc00980f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  The 3'-untranslated region of mRNAs as a site for ribozyme cleavage-dependent processing and control in bacteria.

Authors:  Michele Felletti; Anna Bieber; Jörg S Hartig
Journal:  RNA Biol       Date:  2017-10-11       Impact factor: 4.652

2.  Modularity of select riboswitch expression platforms enables facile engineering of novel genetic regulatory devices.

Authors:  Pablo Ceres; Andrew D Garst; Joan G Marcano-Velázquez; Robert T Batey
Journal:  ACS Synth Biol       Date:  2013-03-28       Impact factor: 5.110

3.  Highly motif- and organism-dependent effects of naturally occurring hammerhead ribozyme sequences on gene expression.

Authors:  Lena A Wurmthaler; Benedikt Klauser; Jörg S Hartig
Journal:  RNA Biol       Date:  2017-12-08       Impact factor: 4.652

4.  In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation.

Authors:  Sean Mc Cafferty; Joyca De Temmerman; Tasuku Kitada; Jacob R Becraft; Ron Weiss; Darrell J Irvine; Mathias Devreese; Siegrid De Baere; Francis Combes; Niek N Sanders
Journal:  Mol Ther       Date:  2020-11-11       Impact factor: 11.454

Review 5.  Antibiotic drugs targeting bacterial RNAs.

Authors:  Weiling Hong; Jie Zeng; Jianping Xie
Journal:  Acta Pharm Sin B       Date:  2014-07-31       Impact factor: 11.413
  5 in total

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